Tlr3/Tlr2 mutant third instar larvae have more eve-positive neurons in the ventral nerve cord compared to wild-type controls.
The ability of hemizygous larvae to encapsulate L.boulardi eggs is significantly reduced compared to that of control larvae. The ability of Tlr2/Tlr3 larvae to encapsulate L.boulardi eggs is significantly reduced compared to that of control larvae. The ability of Tlr2/Tlrv1 larvae to encapsulate L.boulardi eggs is significantly reduced compared to that of control larvae.
Shows brain tumours when heterozygous with the MBT chromosome.
embryos laid by Tlr2/Tlrv19 mothers are dorsalised. They display differentiating amnioserosa tissue around the entire central region of the embryo. Leading edge (LE) and dorsal ectoderm are also formed in these embryos but their axial arrangement is reoriented nearly 90o. Consequently LE cells are arrayed around the dorsal ventral circumference of the embryos, rather than in an anterior to posterior orientation. However, they remain in a single row configuration between amnioserosa and dorsal ectoderm cells. many embryos display a non-uniform distribution of amnioserosa and dorsal ectoderm.
Level of Drs induction of bacterially challenged Tlr2/Tl9QURE mutants is lower than in wild type. Pattern of response of CecA1 and CecA2 parallels that of Drs. Dpt and Dro remain fully inducible and pattern of expression of AttA and Def in intermediate.
At 30oC there are errors in RP motoneuron number at 4 times the frequency seen at 18oC. The defects are similar to those seen for Tl null mutant combination Df(3R)Tl-X/Df(3R)ro-XB3 or hemizygotes. Loss of innervation of muscle fibers 6 and 7 is due to loss of RP3 motoneuron.
Females doubly heterozygous for spz4 and Tlr2 lay weakly dorsalized eggs at 29oC.
Embryos from homozygous females are strongly dorsalised at 29oC and weakly dorsalised at 18oC.
Female hemizygotes produce embryos that develop normally at 18oC but were strongly dorsalized at 29oC. Only 7% survived to adulthood at 29oC. Temperature sensitive period begins late embryogenesis and extended into second larval instar.
temperature-sensitive for the maternal effect, showing stronger dorsalization of the embryonic pattern at 29oC than at 18oC; also temperature-sensitive for viability. TSP for the maternal effect begins slightly before pole cell formation and ends in midsyncytial blastoderm in the offspring of Tlr7 females. TSP for zygotic viability begins late in embryogenesis and extends into the second larval instar in Tlr5 and Tlr6 mutants. recessive