FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Tlrv18
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General Information
Symbol
Dmel\Tlrv18
Species
D. melanogaster
Name
FlyBase ID
FBal0016860
Feature type
allele
Associated gene
Dmel\Tl
Associated Insertion(s)
Carried in Construct
Also Known As
Tl5BRXV
Key Links
Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Gerttula et al., 1988, Tearle and Nusslein-Volhard, 1987)

loss of function allele

(Lindsley and Zimm, 1992)
Mutagen
X ray
(Tearle and Nusslein-Volhard, 1987, Anderson et al., 1985)
Progenitor genotype
Tl2
(Anderson et al., 1985)
Caused by aberration
In(3LR)Tlrv18
Cytology
Description

97D breakpoint located in the 6.0 kb EcoR1 fragment of the Toll clone Tp1.

(Lindsley and Zimm, 1992)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  tauopathy
      modeled by Hsap\MAPTUAS.cWa
      (Feuillette et al., 2020)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Tl[+]/Tlrv18 is an enhancer of visible | adult stage phenotype of Hsap\MAPTUAS.cWa, Scer\GAL4GMR.PF

      (Feuillette et al., 2020)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Tl[+]/Tlrv18 is an enhancer of eye phenotype of Hsap\MAPTUAS.cWa, Scer\GAL4GMR.PF

      (Feuillette et al., 2020)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      5BRXV
      (Riede, 2001)
      Tl1-RXV
      (Tearle and Nusslein-Volhard, 1987)
      Tl5BRXV
      (Gerttula et al., 1988, Anderson et al., 1985)
      Tlrv18
      (Feuillette et al., 2020, Carrell et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)