FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\tor2
Open Close
General Information
Symbol
Dmel\tor2
Species
D. melanogaster
Name
FlyBase ID
FBal0016910
Feature type
allele
Associated gene
Dmel\tor
Associated Insertion(s)
Carried in Construct
Also Known As
torHH
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Sprenger et al., 1993, Sprenger and Nusslein-Volhard, 1992)
Mutagen
ethyl methanesulfonate
(Schupbach and Wieschaus, 1989, Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Amino acid replacement: G556G.

(Sprenger et al., 1993)

Gly at residue 556 (in the tyrosine kinase domain) replaced by Arg.

(Sprenger and Nusslein-Volhard, 1992)

Amino acid replacement: G556R.

(Sprenger and Nusslein-Volhard, 1992)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:7,706,764..7,706,764 [-]
Nucleotide change:

G7706764A

Reported nucleotide change:

G?A

Amino acid change:

G556R | tor-PA; G551R | tor-PD

Reported amino acid change:

G556R

(Sprenger and Nusslein-Volhard, 1992)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos from tor2/torDeg transheterozygous mothers, but not tor2 heterozygous or tor2/tor1 transheterozygous mothers, display a severe failure in primordial germ cell formation, as compared to controls.

      (Pae et al., 2017)

      A hole is seen in the blastoderm layer below the pole cells in embryos. The ventral furrow is extended posteriorly. Segments A8 to the telson are deleted. Segments A5 to A7 are expanded. Some twisting of the germband is seen. Labral and acron-derived structures are deleted. There is cell death in the head and tail region. Cephalic furrow and anterior midgut invagination are shifted anteriorly.

      (Ambrosio et al., 1989)

      Eggs derived from homozygous females cellularise normally but become abnormal at gastrulation; the cephalic furrow is shifted forward, the posterior midgut is missing and the germband forms to the posterior end of the embryo. The embryos lack anterior head structures and structures posterior to segment A7 (the labral segment and telson).

      (Schupbach and Wieschaus, 1989)

      The anteriormost and posteriormost structures are lacking and the anterior pattern is shifted anteriorly. tor embryos display normal levels of bcd protein.

      (Driever and Nusslein-Volhard, 1988)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Schupbach, Wieschaus.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      References (9)