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General Information
Symbol
Dmel\tor2
Species
D. melanogaster
Name
FlyBase ID
FBal0016910
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
torHH
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G7706764A

Reported nucleotide change:

G?A

Amino acid change:

G556R | tor-PA; G551R | tor-PD

Reported amino acid change:

G556R

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: G556G.

Gly at residue 556 (in the tyrosine kinase domain) replaced by Arg.

Amino acid replacement: G556R.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Embryos from tor2/torDeg transheterozygous mothers, but not tor2 heterozygous or tor2/tor1 transheterozygous mothers, display a severe failure in primordial germ cell formation, as compared to controls.

A hole is seen in the blastoderm layer below the pole cells in embryos. The ventral furrow is extended posteriorly. Segments A8 to the telson are deleted. Segments A5 to A7 are expanded. Some twisting of the germband is seen. Labral and acron-derived structures are deleted. There is cell death in the head and tail region. Cephalic furrow and anterior midgut invagination are shifted anteriorly.

Eggs derived from homozygous females cellularise normally but become abnormal at gastrulation; the cephalic furrow is shifted forward, the posterior midgut is missing and the germband forms to the posterior end of the embryo. The embryos lack anterior head structures and structures posterior to segment A7 (the labral segment and telson).

The anteriormost and posteriormost structures are lacking and the anterior pattern is shifted anteriorly. tor embryos display normal levels of bcd protein.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Schupbach, Wieschaus.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (9)