FlyBase Allele Report: Dmel\trk[1]

General Information

Symbol

Dmel\trk¹

Species

D. melanogaster

Name

FlyBase ID

FBal0017039

Feature type

allele

Associated gene

Dmel\trk

Associated Insertion(s)

Carried in Construct

Also Known As

trk^RA, trk^RA41

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Casanova et al., 1995, Ray et al., 1991, Casanova and Struhl, 1989)

Mutagen

ethyl methanesulfonate

(Casanova et al., 1995, Schupbach and Wieschaus, 1989)

Progenitor genotype

Cytology

Description

Nucleotide substitution: G?A.

(Casanova, 1999.9.6)

Amino acid replacement: W211term.

(Casanova, 1999.9.6, Casanova et al., 1995)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:10,271,550..10,271,550 [-]

Nucleotide change:

G10271550A

Reported nucleotide change:

G?A

Amino acid change:

W220term | trk-PA

Reported amino acid change:

W211term

Comment:

TGG to TGA; difference between reported and annotated amino acid number is due to authors using M10 as the start Met.

(Casanova et al., 1995)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile | recessive

(Schupbach and Wieschaus, 1989)

lethal | maternal effect

(Casanova et al., 1995)

lethal - all die during embryonic stage | maternal effect | recessive

(Schupbach and Wieschaus, 1989)

some die during embryonic stage | recessive | maternal effect | recessive

(Schupbach and Wieschaus, 1989)

visible | embryonic stage | recessive

(Rewitz et al., 2009)

Phenotype Manifest In

abdomen

(Casanova et al., 1995)

abdominal 8 ventral denticle belt

(Rewitz et al., 2009)

abdominal 9 ventral denticle belt

(Rewitz et al., 2009)

abdominal segment 8

(Schupbach and Wieschaus, 1986)

cephalic furrow | maternal effect

(Schupbach and Wieschaus, 1989)

embryo | extended germ band stage | maternal effect

(Schupbach and Wieschaus, 1989)

embryonic/first instar larval cuticle | maternal effect

(Schupbach and Wieschaus, 1989)

embryonic abdominal segment 8 | maternal effect

(Ding et al., 2010)

embryonic labral segment | maternal effect

(Schupbach and Wieschaus, 1989)

filzkorper

(Rewitz et al., 2009)

filzkorper | maternal effect

(Ding et al., 2010)

labrum

(Schupbach and Wieschaus, 1986)

posterior endoderm | maternal effect

(Schupbach and Wieschaus, 1989)

posterior midgut primordium | maternal effect

(Schupbach and Wieschaus, 1989)

telson

(Schupbach and Wieschaus, 1986)

telson | maternal effect

(Schupbach and Wieschaus, 1989)

Detailed Description

Statement

Reference

Embryos derived from homozygous females show deletion of posterior structures (abdominal segment 8 and Filzkorper).

(Ding et al., 2010)

Denticle belts posterior to the seventh abdominal segment and the Filzkorper are missing in trk¹ mutants.

(Rewitz et al., 2009)

Defective in gonad assembly.

(Warrior, 1994)

Posterior defect is significantly suppressed, in a dose-dependent manner, by Dsor1^Su1.

(Tsuda et al., 1993)

In tor¹ trk¹ embryos little or no tll expression is detected in the posterior of syncytial or cellular blastoderm embryos, at the anterior the early tll cap does not appear and an abnormal anterior tll stripe appears by the late syncytial blastoderm.

(Pignoni et al., 1992)

Interacts with RpII140^wimp maternal effect.

(Parkhurst and Ish-Horowicz, 1991)

Dorsalized embryos: all cuticle cells along the dorsoventral axis behave like dorsal cells of the wild type embryo. zen expression pattern refines at stage 5, dpp pattern does not refine at all, twi and sna are expressed during late stages of embryogenesis. Differentiated embryos lack the labrum, head skeleton is reduced in size and all structures posterior to the seventh abdominal segment are deleted.

(Ray et al., 1991)

Embryos derived from tor¹, trk¹ females lack A8 and filzkorper. Filzkorper are formed and segmentation is repressed in heat shocked embryos carrying tll^hs.PS and derived from tor¹, trk¹ females.

(Steingrimsson et al., 1991)

Loss of supraoesophageal ganglion and dorsal shift in the position of the suboesophageal ganglion.

(Strecker et al., 1991)

A single tor^11D allele variably suppresses the phenotype caused by trk¹ in embryos derived from females homozygous for trk¹ and heterozygous for tor^11D, depending on the temperature.

(Casanova and Struhl, 1989)

Eggs derived from homozygous females cellularise normally but become abnormal at gastrulation; the cephalic furrow is shifted forward, the posterior midgut is missing and the germband forms to the posterior end of the embryo. The embryos lack anterior head structures and structures posterior to segment A7 (the labral segment and telson).

(Schupbach and Wieschaus, 1989)

In the anterior labral and acronal derivatives are missing. Significant reduction in size of supraoesophageal ganglion. In the posterior ectodermal and endodermal structures are affected.

(Strecker et al., 1988)

Homozygous females produce embryos which have deletions of the most anterior head structures (labrum and chitinous mouth plates), and the most posterior abdominal structures (posterior midgut, telson and abdominal segment A8).

(Schupbach and Wieschaus, 1986)

embryos from homozygous mothers lack anterior-most head structures and structures posterior to the seventh abdominal segment. At gastrulation cephalic furrow is shifted toward anterior and the germband extends all the way to the posterior end. During cellularization at the blastoderm stage a funnel of yolk free cytoplasm containing a small number of nuclei (between 10 and 30) forms at the posterior pole of the embryos extending from the egg periphery to the inner yolk mass. Analysis of germ-line clones indicates that the mutation is germ-line autonomous (Schupbach and Wieschaus, 1986).

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

trk¹ has visible | recessive | embryonic stage phenotype, suppressible by Scer\GAL4^{VP16.nanos.UTR}/Ptth^UAS.Tag:HA

(Rewitz et al., 2009)

Phenotype Manifest In

Enhanced by

Statement

Reference

tor^11D, trk[+]/trk¹ has embryonic segment | maternal effect phenotype, enhanceable | maternal effect by cic¹/cic[+]

(de las Heras and Casanova, 2006)

tor^11D, trk[+]/trk¹ has embryonic/first instar larval cuticle | maternal effect phenotype, enhanceable | maternal effect by cic¹/cic[+]

(de las Heras and Casanova, 2006)

Suppressed by

Statement

Reference

trk¹ has embryonic abdominal segment 8 | maternal effect phenotype, suppressible by Raf^Hsp83.PD

(Ding et al., 2010)

trk¹ has abdominal 8 ventral denticle belt phenotype, suppressible by Scer\GAL4^{VP16.nanos.UTR}/Ptth^UAS.Tag:HA

(Rewitz et al., 2009)

trk¹ has abdominal 9 ventral denticle belt phenotype, suppressible by Scer\GAL4^{VP16.nanos.UTR}/Ptth^UAS.Tag:HA

(Rewitz et al., 2009)

trk¹ has filzkorper phenotype, suppressible by Scer\GAL4^{VP16.nanos.UTR}/Ptth^UAS.Tag:HA

(Rewitz et al., 2009)

cic¹/cic[+], tor^11D, trk¹ has embryonic segment | maternal effect phenotype, suppressible | maternal effect | partially by Stat92E[+]/Stat92E⁰⁶³⁴⁶

(de las Heras and Casanova, 2006)

cic¹/cic[+], tor^11D, trk[+]/trk¹ has embryonic/first instar larval cuticle | maternal effect phenotype, suppressible | maternal effect | partially by Stat92E[+]/Stat92E⁰⁶³⁴⁶

(de las Heras and Casanova, 2006)

NOT suppressed by

Statement

Reference

trk¹ has embryonic abdominal segment 8 | maternal effect phenotype, non-suppressible by Raf^Hsp83.PD

(Ding et al., 2010)

Enhancer of

Statement

Reference

trk[+], tor[+], trk¹, tor^11D is an enhancer of embryonic/first instar larval cuticle phenotype of cic¹

(de las Heras and Casanova, 2006)

Suppressor of

Statement

Reference

trk¹ is a suppressor of embryonic segment phenotype of tsl^tor.PF

(Furriols et al., 1998)

Other

Statement

Reference

tor^11D, trk[+]/trk¹ has embryonic/first instar larval cuticle | maternal effect phenotype

(de las Heras and Casanova, 2006)

tor^11D, trk[+]/trk¹ has abdominal segment | maternal effect phenotype

(de las Heras and Casanova, 2006)

tor[+]/tor^11D, trk¹ has embryonic/first instar larval cuticle phenotype

(de las Heras and Casanova, 2006)

tor[+]/tor^11D, trk¹ has abdominal segment phenotype

(de las Heras and Casanova, 2006)

Additional Comments

Genetic Interactions

Statement

Reference

phl^Hsp83.PD partially restores abdominal segment 8 denticle belts in embryos derived from homozygous trk¹ females.

phl^ΔN114.Hsp83 does not rescue abdominal segment 8 denticle belts in embryos derived from homozygous trk¹ females.

(Ding et al., 2010)

The missing denticle belt and Filzkorper cuticle structures are partially restored in trk¹ mutants by Ptth^Scer\UAS.cMa overexpression driven by Scer\GAL4^{nos.UTR.T:Hsim\VP16}.

(Rewitz et al., 2009)

Cuticles made by embryos from trk¹+ ; tor^11D/+ mothers embryos occasionally lack one abdominal segment.

The segmentation defects seen in embryos from cic¹ homozygous are enhanced if the mothers are also trk¹/+; tor^11D/+.

(de las Heras and Casanova, 2006)

Embryos from trk¹ females carrying tsl^tor.PF show no rescue of the trk¹ phenotype and do not show deletions of the middle segments ("splice" phenotype seen in wild-type embryos carrying tsl^tor.PF).

(Furriols et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

trk¹ is rescued by trk^+t3004

(Casanova et al., 1995)

Comments

Homozygous embryos exhibit terminal patterning defects, these can be fully rescued by trk^+t3004.

(Casanova et al., 1995)

Images (0)

Mutant

Wild-type

Stocks (3)

Bloomington

92603

trk¹/CyO; P{UAS-trk.C}8.4.1

606556

trk¹ cn¹ bw¹; P{TR11}3/TM2

Kyoto

106247

trk¹ cn¹/CyO

Notes on Origin

Discoverer

Comments

Germline mosaic analysis shows that trk is required in the germline.

(Schupbach and Wieschaus, 1986)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

tll^RA41

(Strecker et al., 1988)

trk¹

(Ho et al., 2025, Johnson et al., 2020, Grimm et al., 2012, Christensen et al., 2009.7.22, Rewitz et al., 2009, Christensen and Cook, 2006.8.30, de las Heras and Casanova, 2006, Casanova, 1999.9.6)

trk^RA41

(Murakami et al., 1995, Tsuda et al., 1993, Parkhurst and Ish-Horowicz, 1991)

trk^RA

(Warrior, 1994, Pignoni et al., 1992, Casanova, 1991, Ray et al., 1991, Steingrimsson et al., 1991, Casanova and Struhl, 1989, Schupbach and Wieschaus, 1986)

trunk¹

(Ding et al., 2010)

trunk^RA41

(Jackson and Hoffmann, 1994)

Name Synonyms

Secondary FlyBase IDs

References (29)

Report Sections

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