FlyBase Allele Report: Dmel\wb[09437]

General Information

Symbol

Dmel\wb⁰⁹⁴³⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0018476

Feature type

allele

Associated gene

Dmel\wb

Associated Insertion(s)

P{PZ}wb⁰⁹⁴³⁷

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

Progenitor genotype

Associated Insertion(s)

P{PZ}wb⁰⁹⁴³⁷

Cytology

Description

P{PZ} insertion within an intron.

(Ashburner et al., 1999)

P{PZ} insertion at position 15219 of DS03792.

(Ashburner et al., 1999.10.12)

P{PZ} insertion in the fourth intron.

(Martin et al., 1999)

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:14,288,960..14,319,552 [+]

(Thuveson et al., 2019, Han et al., 2012, Brown and Freeman, 2003, Ashburner et al., 1999, Ashburner et al., 1999, Ashburner et al., 1999.10.12, Martin et al., 1999, Spradling et al., 1999, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Ashburner et al., 1999)

lethal | recessive

(Ashburner et al., 1999, Spradling et al., 1999, Roote, 1995.5.15)

lethal - all die during embryonic stage | recessive

(Martin et al., 1999)

some die during embryonic stage | recessive

(Martin et al., 1999)

Phenotype Manifest In

wing

(Martin et al., 1999)

Detailed Description

Statement

Reference

wb¹/wb⁰⁹⁴³⁷ flies show blistering of the wing.

(Martin et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

wb⁰⁹⁴³⁷ is a non-enhancer of abnormal cell polarity phenotype of S⁰⁵⁶⁷¹

(Brown and Freeman, 2003)

NOT Suppressor of

Statement

Reference

wb⁰⁹⁴³⁷ is a non-suppressor of abnormal cell polarity phenotype of S⁰⁵⁶⁷¹

(Brown and Freeman, 2003)

Other

Statement

Reference

mys¹/mys[+], wb⁰⁹⁴³⁷ has abnormal neuroanatomy | third instar larval stage phenotype

(Han et al., 2012)

mew[+]/mew^M6, wb⁰⁹⁴³⁷ has abnormal neuroanatomy | third instar larval stage phenotype

(Han et al., 2012)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

wb⁰⁹⁴³⁷ is a non-enhancer of ommatidium phenotype of S⁰⁵⁶⁷¹

(Brown and Freeman, 2003)

NOT Suppressor of

Statement

Reference

wb⁰⁹⁴³⁷ is a non-suppressor of ommatidium phenotype of S⁰⁵⁶⁷¹

(Brown and Freeman, 2003)

Other

Statement

Reference

mys¹/mys[+], wb⁰⁹⁴³⁷ has larval dorsal multidendritic neuron ddaC | third instar larval stage phenotype

(Han et al., 2012)

mew[+]/mew^M6, wb⁰⁹⁴³⁷ has larval dorsal multidendritic neuron ddaC | third instar larval stage phenotype

(Han et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

mys¹/wb⁰⁹⁴³⁷ mutant third instar larvae show a mild but statistically significant increase in the proportion of dorsal midline ddaC dendritic length that is enclosed within the epidermis rather than attached to the ECM. The amount of enclosed dendrite seen in each heterozygote is similar to wild type.

mew^M6/wb⁰⁹⁴³⁷ mutant third instar larvae show a mild but statistically significant increase in the proportion of dorsal midline ddaC dendritic length that is enclosed within the epidermis rather than attached to the ECM. The amount of enclosed dendrite seen in each heterozygote is similar to wild type.

(Han et al., 2012)

wb⁰⁹⁴³⁷ has no effect on the S⁰⁵⁶⁷¹/+ ommatidial polarity phenotype.

(Brown and Freeman, 2003)

S^48-5/wb⁴⁴¹⁸ mutants show 7.17%+-0.60 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone.

(Gaengel and Mlodzik, 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

wb^unspecified

(Martin et al., 1999)

wb¹⁰⁰⁰²

(BDGP Project Members, 1994-1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

12362

cn¹ P{PZ}wb⁰⁹⁴³⁷/CyO; ry⁵⁰⁶

Notes on Origin

Discoverer

A. Spradling.

Comments

Complements: cenG1A⁰⁶⁶⁴⁶. Complements: l(2)35Bd¹⁰⁴⁰⁸.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

PZ09437

(Ashburner et al., 1999)

l(2)09437

(Spradling et al., 1999)

wb-09437

(Gaengel and Mlodzik, 2003)

wb⁰⁹⁴³⁷

(Thuveson et al., 2019, Han et al., 2012, Vanderploeg et al., 2012, Inoue and Hayashi, 2007)

wb^PZ09437

(Martin et al., 1999)

wb^PZ12

(Roote, 1995.5.15)

Name Synonyms

Secondary FlyBase IDs

References (15)

Report Sections

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