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General Information
Symbol
Dmel\Abd-BFab7-2
Species
D. melanogaster
Name
FlyBase ID
FBal0028657
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Fab-72, Fab72
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference

Deletion of DNA.

Imprecise excision of the P{bluetail} insertion deleting the major hypersensitive sites HS1 and HS2 but leaving HS3.

Deletion of two of the three DNaseI hypersensitive sites within the Fab-7 element.

Gene conversion event in which the P{bluetail}Abd-Bblt insertion has been excised and the gap has been repaired using a P{Abd-BFab7-2} insertion at 12E as the donor template. This results in a specific deletion of 789bp in the Fab-7 boundary region.

789bp deletion with a lesion in the Fab7 domain.

The P insertion plus 0.7kb of proximal flanking DNA is deleted, including at least one and possibly all of two of the three nuclease hypersensitive regions.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous Abd-BFab7-2 mutant adult flies primarily show an A6 to A7 transformation, as evidenced by the reduction of the A6 tergite.

A6 assumes A7 identity in Abd-BFab7-2 males, so that in adults most of the sixth tergite and sternite are absent. Some cells of A6 are visible as a small tergite which adopts A5 identity.

In Abd-BFab7-2 heterozygous males the 6th segment (A6) assumes A7 identity: most of the sixth sternite and tergite are absent.

Heterozygous males have a reduced A6 segment.

Incomplete transformation of PS11 to PS12.

Homozygotes show incomplete transformation of abdominal segment A6 to A7.

Transforms parasegment 11 to parasegment 12 identity.

Incomplete transformation of abdominal segment 6 to A7 identity.

A6 is incompletely transformed into A7 in homozygotes. In homozygotes, a rudimentary 6th tergite is present.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference

Abd-BFab7-2 has abdominal segment 6 phenotype, enhanceable by barr[+]/barrL305

Abd-BFab7-2 has phenotype, enhanceable by Pc3

Abd-BFab7-2 has phenotype, enhanceable by ScmD1

Abd-BFab7-2 has phenotype, enhanceable by Df(2R)trix

Abd-BFab7-2 has phenotype, enhanceable by Pcl10

Additional Comments
Genetic Interactions
Statement
Reference

When barrL305/+ is added to Abd-BFab7-2/+, nearly a complete reduction of abdominal segment A6 in 17%-31% of animals.

The heterozygous gain of function phenotype is enhanced by Polycomb group mutations such as Pc3, Pcl10, ScmD1 and Df(2R)trix.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Associated with: Fab-72.

Comments
Comments

Deletion removes the prominent nuclear hypersensitive sites I and II.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
References (12)