FlyBase Allele Report: Dmel\Pcl[10]

General Information

Symbol

Dmel\Pcl¹⁰

Species

D. melanogaster

Name

FlyBase ID

FBal0013617

Feature type

allele

Associated gene

Dmel\Pcl

Associated Insertion(s)

Carried in Construct

Also Known As

Pcl^T1

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

gamma ray

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Gindhart and Kaufman, 1995)

Mutagen

gamma ray

(Lindsley and Zimm, 1992)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | adult stage | dominant

(Brizuela and Kennison, 1997)

visible | dominant | homeotic

(Brizuela and Kennison, 1997)

Phenotype Manifest In

mesothoracic leg

(Brizuela and Kennison, 1997)

metathoracic leg

(Brizuela and Kennison, 1997)

Detailed Description

Statement

Reference

Heterozygous adults have sex comb teeth on the second and third legs. The penetrance of this phenotype is 97% and the expressivity is 12%.

(Brizuela and Kennison, 1997)

Pairing sensitive repression is alleviated in iab-7 PRE lines that carry Pcl¹⁰.

(Hagstrom et al., 1997)

The penetrance of the second and third leg to first leg transformation in Pcl¹⁰ heterozygotes carrying two brm⁺ alleles is 97%, but only 5% in flies heterozygous for Pcl¹⁰ and brm².

(Tamkun et al., 1992)

Haplo-abnormal phenotype is suppressed by a duplication carrying Pc.

(Kennison and Russell, 1987)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Pcl¹⁰ has visible | dominant | homeotic phenotype, suppressible by mor¹

(Brizuela and Kennison, 1997)

Pcl¹⁰ has visible | dominant | adult stage phenotype, suppressible by mor¹

(Brizuela and Kennison, 1997)

Pcl¹⁰ has visible | dominant | homeotic phenotype, suppressible by mor²

(Brizuela and Kennison, 1997)

Pcl¹⁰ has visible | dominant | adult stage phenotype, suppressible by mor²

(Brizuela and Kennison, 1997)

Enhancer of

Statement

Reference

Pcl¹⁰/Pcl[+] is an enhancer of visible | dominant | homeotic phenotype of Pc⁴

(Kehle et al., 1998)

Phenotype Manifest In

Enhanced by

Statement

Reference

Pcl¹⁰ has sex comb | ectopic phenotype, enhanceable by gpp[+]/gpp⁸

(Shanower et al., 2005)

Pcl¹⁰ has sex comb | ectopic phenotype, enhanceable by gpp[+]/gpp^1A

(Shanower et al., 2005)

Pcl¹⁰ has sex comb | ectopic phenotype, enhanceable by gpp[+]/gpp^94A

(Shanower et al., 2005)

Pcl¹⁰ has sex comb | ectopic phenotype, enhanceable by gpp[+]/gpp^X

(Shanower et al., 2005)

Pcl¹⁰ has sex comb | ectopic phenotype, enhanceable by gpp[+]/gpp^XXV

(Shanower et al., 2005)

Suppressed by

Statement

Reference

Pcl¹⁰ has sex comb phenotype, suppressible by mor²

(Brizuela and Kennison, 1997)

Pcl¹⁰ has mesothoracic leg phenotype, suppressible by mor¹

(Brizuela and Kennison, 1997)

Pcl¹⁰ has metathoracic leg phenotype, suppressible by mor¹

(Brizuela and Kennison, 1997)

Pcl¹⁰ has sex comb phenotype, suppressible by mor¹

(Brizuela and Kennison, 1997)

Pcl¹⁰ has mesothoracic leg phenotype, suppressible by mor²

(Brizuela and Kennison, 1997)

Pcl¹⁰ has metathoracic leg phenotype, suppressible by mor²

(Brizuela and Kennison, 1997)

Enhancer of

Statement

Reference

Pcl¹⁰/Pcl[+] is an enhancer of mesothoracic leg phenotype of Pc⁴

(Kehle et al., 1998)

Pcl¹⁰/Pcl[+] is an enhancer of metathoracic leg phenotype of Pc⁴

(Kehle et al., 1998)

Pcl¹⁰/Pcl[+] is an enhancer of sex comb | ectopic phenotype of Pc⁴

(Kehle et al., 1998)

Pcl¹⁰ is an enhancer of phenotype of Abd-B^Fab7-24

(Mihaly et al., 1997)

Pcl¹⁰ is an enhancer of phenotype of Abd-B^Fab7-P18.1

(Mihaly et al., 1997)

Pcl¹⁰ is an enhancer of phenotype of Abd-B^Fab7-33

(Mihaly et al., 1997)

Pcl¹⁰ is an enhancer of phenotype of Abd-B^Fab7-14

(Mihaly et al., 1997)

Pcl¹⁰ is an enhancer of phenotype of Abd-B^Fab7-32

(Mihaly et al., 1997)

Pcl¹⁰ is an enhancer of phenotype of Abd-B^Fab7-P14.1

(Mihaly et al., 1997)

Pcl¹⁰ is an enhancer of phenotype of Abd-B^Fab7-19

(Mihaly et al., 1997)

Pcl¹⁰ is an enhancer of phenotype of Abd-B^Fab7-3

(Mihaly et al., 1997)

Pcl¹⁰ is an enhancer of phenotype of Abd-B^Fab7-P6.1

(Mihaly et al., 1997)

Pcl¹⁰ is an enhancer of phenotype of Abd-B^Fab7-28

(Mihaly et al., 1997)

Pcl¹⁰ is an enhancer of phenotype of Abd-B^Fab7-2

(Mihaly et al., 1997)

NOT Enhancer of

Statement

Reference

Pcl¹⁰ is a non-enhancer of sex comb phenotype of Scr²

(Southworth and Kennison, 2002)

Suppressor of

Statement

Reference

Pcl¹⁰ is a suppressor of wing phenotype of sd^Fab-X

(Bantignies et al., 2003)

NOT Suppressor of

Statement

Reference

Pcl¹⁰ is a non-suppressor of sex comb phenotype of Scr²

(Southworth and Kennison, 2002)

Additional Comments

Genetic Interactions

Statement

Reference

The average number of sex comb teeth per first leg Scr²/+ males is not affected if they are also carrying Pcl¹⁰.

(Southworth and Kennison, 2002)

Mutant heterozygotes show a moderate suppression of the eye phenotype see in P{UAS-lacZ.Abd-B.5F24} leading to darker eyes.

(Cavalli, 1999)

The addition of heterozygous Pcl¹⁰ can suppress the Pairing sensitive silencing effect seen in w^Mcp.10, w^Mcp.13, w^{Mcp.scs'.12:15}, and w^Mcp.scs'.14. The addition of heterozygous Pcl¹⁰ has no effect on the Pairing sensitive silencing effect seen in w^Mcp.11, w^Mcp.scs'.11 and w^Mcp.scs'.21 nor does it have any effect on the eye colour of w^Mcp.scs'.21/y^we.Mcp.1 (P{Mcp-w#21}124/+, P{Mcp-wy#1}183/+) double heterozygous insertions. Though in the case of w^Mcp.scs'.11, a darker eye colour can be seen at 18^oC. The addition of heterozygous Pcl¹⁰ suppresses the Pairing sensitive silencing effect seen in w^Mcp.scs'.11 (P{Mcp-w#11}16/+, P{Mcp-w#11}102/+) double heterozygous insertions. The addition of heterozygous Pcl¹⁰ suppresses the Pairing sensitive silencing effect seen in w^Mcp.scs'.14/ w^Mcp.13 (P{Mcp-w#14}AP-2^stummelbein/+, P{Mcp-w#13}116/+) and the eye colour of w^Mcp.y.scs'.1/y^we.Mcp.2 (P{Mcp-yw#1}103/+, P{Mcp-wy#2}50/+) double heterozygous insertions.

(Muller et al., 1999)

The formation of extra sex combs on the second and third legs in Pc⁴/+ flies is dominantly enhanced by Pcl¹⁰.

(Kehle et al., 1998)

The penetrance and expressivity of the Pcl¹⁰/+ transformation phenotype is dominantly suppressed by mor¹ or mor².

(Brizuela and Kennison, 1997)

Enhances the transformation of A6 to A7 seen in Abd-B^Fab7-P18.1 heterozygotes, but does not alter the phenotype of Abd-B^Fab7-12 heterozygotes.

(Mihaly et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Tiong.

(Lindsley and Zimm, 1992)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Pcl¹⁰

(Bantignies et al., 2011)

Pcl^T1

(Park et al., 2023, Vaziri et al., 2020, Bengani et al., 2013, Vasanthi et al., 2013, Chanas and Maschat, 2005, Shanower et al., 2005, Cavalli, 1999, Muller et al., 1999, Mihaly et al., 1997, Kennison and Russell, 1987)

Name Synonyms

Secondary FlyBase IDs

FBal0065029

References (21)

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