FlyBase Allele Report: Dmel\gpp[1A]

General Information

Symbol

Dmel\gpp^1A

Species

D. melanogaster

Name

FlyBase ID

FBal0175662

Feature type

allele

Associated gene

Dmel\gpp

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Shanower et al., 2005)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal stress response | adult stage

(List et al., 2009)

non-enhancer of variegation, with P{hsp26-pt-T}39C-4

(Shanower et al., 2005)

non-enhancer of variegation, with P{hsp26-pt-T}39C-5

(Shanower et al., 2005)

non-enhancer of variegation, with P{hsp26-pt-T}39C-27

(Shanower et al., 2005)

non-enhancer of variegation, with P{hsp26-pt-T}39C-31

(Shanower et al., 2005)

non-enhancer of variegation, with P{hsp26-pt-T}39C-50

(Shanower et al., 2005)

non-enhancer of variegation, with P{hsp26-pt-T}39C-55

(Shanower et al., 2005)

non-enhancer of variegation, with P{hsp26-pt-T}39C-62

(Shanower et al., 2005)

non-enhancer of variegation, with P{hsp26-pt-T}39C-72

(Shanower et al., 2005)

non-enhancer of variegation, with P{hsp26-pt-T}118E-10

(Shanower et al., 2005)

non-enhancer of variegation, with P{hsp26-pt-T}118E-12

(Shanower et al., 2005)

non-enhancer of variegation, with P{hsp26-pt-T}Dyrk3^118E-15

(Shanower et al., 2005)

non-suppressor of variegation, with P{hsp26-pt-T}39C-4

(Shanower et al., 2005)

non-suppressor of variegation, with P{hsp26-pt-T}39C-5

(Shanower et al., 2005)

non-suppressor of variegation, with P{hsp26-pt-T}39C-27

(Shanower et al., 2005)

non-suppressor of variegation, with P{hsp26-pt-T}39C-31

(Shanower et al., 2005)

non-suppressor of variegation, with P{hsp26-pt-T}39C-50

(Shanower et al., 2005)

non-suppressor of variegation, with P{hsp26-pt-T}39C-55

(Shanower et al., 2005)

non-suppressor of variegation, with P{hsp26-pt-T}39C-62

(Shanower et al., 2005)

non-suppressor of variegation, with P{hsp26-pt-T}39C-72

(Shanower et al., 2005)

non-suppressor of variegation, with P{hsp26-pt-T}118E-10

(Shanower et al., 2005)

non-suppressor of variegation, with P{hsp26-pt-T}118E-12

(Shanower et al., 2005)

non-suppressor of variegation, with P{hsp26-pt-T}Dyrk3^118E-15

(Shanower et al., 2005)

short lived

(List et al., 2009)

viable

(List et al., 2009, Shanower et al., 2005)

visible | male

(Shanower et al., 2005)

Phenotype Manifest In

Detailed Description

Statement

Reference

Mutant flies have a reduced adult lifespan compared to controls (at both 30[o]C ad 25[o]C).

Mutant flies show decreased resistance to oxidative stress (1% hydrogen peroxide) compared to controls.

(List et al., 2009)

Abdominal segments A5 and A6 are transformed towards an A4 identity in homozygous males. The tergites show posterior-to-anterior transformation, there is almost complete loss of male pigmentation in A5 and A6 and hairs are seen on the sixth sternite. A vestigial "A7" tergite, that is not normally present in males, is seen.

(Shanower et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

gpp[+]/gpp^1A is an enhancer of visible | dominant phenotype of Abd-B^M1

(Shanower et al., 2005)

Phenotype Manifest In

Enhancer of

Statement

Reference

gpp[+]/gpp^1A is an enhancer of sex comb | ectopic phenotype of Pcl¹⁰

(Shanower et al., 2005)

gpp[+]/gpp^1A is an enhancer of male genitalia phenotype of Abd-B^M1

(Shanower et al., 2005)

gpp[+]/gpp^1A is an enhancer of sex comb | ectopic phenotype of Scm^D1

(Shanower et al., 2005)

gpp[+]/gpp^1A is an enhancer of sex comb | ectopic phenotype of Sce¹

(Shanower et al., 2005)

Suppressor of

Statement

Reference

gpp[+]/gpp^1A is a suppressor of sex comb | ectopic phenotype of Pc³

(Shanower et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

gpp^1A suppresses the pairing-sensitive silencing seen in flies carrying in cis pairs of transgenes that contain MCP-PRE (P{Mcp-ff#13}101 and P{Mcp-w#14}AP-2^stummelbein, or P{Mcp-w#11}16 and P{Mcp-w#11}102 or P{Mcp-wy#2}63 and P{Mcp-ff#15}30). The penetrance of the rotated genitalia phenotype seen in Abd-B^M1 males is enhanced if they are also heterozygous for gpp^1A. The enhancement is stronger if the gpp allele is inherited maternally.

(Shanower et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: a mutation that dominantly suppresses pairing-sensitive silencing of the mini-w gene in P{Mcp-ff#10}5 or P{Fab7-w#un3}18.73.1.

(Shanower et al., 2005)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

gpp^1A

(List et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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