FlyBase Allele Report: Dmel\Abd-B[M1]

Abd-B^M1 homozygous mutant MARCM clones (induced using hs-FLP during the embryonic stage) in the terminal region of the female third instar larval ventral nerve cord have surviving doublesex-expressing larval terminal neuroblasts, unlike controls.

(Ghosh et al., 2019)

In Abd-B^T2N/Abd-B^M1 hemizygotes the seventh abdominal tergite (T7) is fully developed, indicating a transformation toward a more anterior abdominal segment identity when compared with wild-type. The eighth abdominal tergite (T8) also shows a partial transformation toward a more anterior identity.

(Ho et al., 2011)

In Abd-B^M1/Abd-B^Uab-1 embryos, the genital disc primordium is disorganised and contains about eight cells. Abd-B^M1 embryos exhibit a few scattered hdc-expressing cells, occasionally forming lateral groups within the A8 segment.

(Foronda et al., 2006)

In Abd-B^M1 mutants, the posterior spiracles fail to form.

(Lovegrove et al., 2006)

Abd-B^LDN/Abd-B^M1 female flies show an absence of genitalia. Occasionally these flies have a small eighth sternite with a few bristles. Abd-B^LDN/Abd-B^M1 females have an abnormally large seventh tergite and this tergite is also present in Abd-B^LDN/Abd-B^M1 males, although it is not present in wild-type males.

(de Navas et al., 2006)

Heterozygous males show a rotated genitalia phenotype.

(Shanower et al., 2005)

In mutant embryos the posterior spiracle does not form, there is no spiracle lumen and the trachea opens to the surface directly through the spiracular branch. The stigma of A8 does not slide posteriorly, as it would in wild type, but stays in the same position as in anterior abdominal segments.

(Hu and Castelli-Gair, 1999)

Mutants lack posterior spiracles but form a well developed A8 ventral denticle belt.

(Castelli-Gair, 1998)

Homozygous embryos do not show defects in the peripheral nervous system in abdominal segment A7. The spiracle neurons of abdominal segment A8 are missing.

(Castelli-Gair, 1998)

No gross morphological defects are seen in the central nervous system of Ubx^9.22 Abd-B^M1 double mutant embryos.

(Hirth et al., 1998)

abd-A^hs.PS Abd-B^M5 heat induced embryos exhibit transformation of segment A8 to an anterior abdominal segment and transformation of A9 to an anterior abdominal segment of the A2-A6 type. Sclerotic plates are absent.

(Sanchez-Herrero et al., 1994)

A5-A8 (including female genitalia) transformed to A4 in mosaics. Embryos have sclerotic plates in pA8 and occasional extra denticles in A9, and parasegments 10-13 are transformed to parasegment 9.

(Sanchez-Herrero and Crosby, 1988)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Abd-B^M1 has visible | dominant phenotype, enhanceable by gpp[+]/gpp^61A

(Shanower et al., 2005)

Abd-B^M1 has visible | dominant phenotype, enhanceable by gpp[+]/gpp^1A

(Shanower et al., 2005)

NOT Enhanced by

Statement

Reference

Abd-B^MD761/Abd-B^M1, Abd-B^UAS.m, Scer\GAL4^Abd-B-MD761 has visible | adult stage | male phenotype, non-enhanceable by exd^GD1439, Scer\GAL4^Abd-B-MD761

(Curt et al., 2025)

NOT suppressed by

Statement

Reference

Abd-B^MD761/Abd-B^M1, Abd-B^UAS.m, Scer\GAL4^Abd-B-MD761 has visible | male | adult stage phenotype, non-suppressible by exd^GD1439, Scer\GAL4^Abd-B-MD761

(Curt et al., 2025)

Phenotype Manifest In

Enhanced by

Statement

Reference

Abd-B^M1 has male genitalia phenotype, enhanceable by gpp[+]/gpp^61A

(Shanower et al., 2005)

Abd-B^M1 has male genitalia phenotype, enhanceable by gpp[+]/gpp^1A

(Shanower et al., 2005)

NOT Enhanced by

Statement

Reference

Abd-B^MD761/Abd-B^M1, Abd-B^UAS.m, Scer\GAL4^Abd-B-MD761 has adult abdominal segment 7 | ectopic | male phenotype, non-enhanceable by exd^GD1439, Scer\GAL4^Abd-B-MD761

(Curt et al., 2025)

NOT suppressed by

Statement

Reference

Abd-B^MD761/Abd-B^M1, Abd-B^UAS.m, Scer\GAL4^Abd-B-MD761 has adult abdominal segment 7 | ectopic | male phenotype, non-suppressible by exd^GD1439, Scer\GAL4^Abd-B-MD761

(Curt et al., 2025)

Abd-B^M1/Abd-B^LDN has female genitalia phenotype, non-suppressible by abd-A^1dB5.UAS/Scer\GAL4^Abd-B-LDN

(de Navas et al., 2006)

Abd-B^M1/Abd-B^LDN has abdominal tergite 7 phenotype, non-suppressible by abd-A^1dB5.UAS/Scer\GAL4^Abd-B-LDN

(de Navas et al., 2006)

Abd-B^M1/Abd-B^LDN has abdominal tergite 7 | ectopic | male phenotype, non-suppressible by abd-A^1dB5.UAS/Scer\GAL4^Abd-B-LDN

(de Navas et al., 2006)

Other

Statement

Reference

Abd-B^M1, Scer\GAL4^69B, ct^UAS.cLa, ems^UAS.cSa, grn^UAS.cBa, upd1^UAS.cZa has embryonic/larval spiracle | ectopic phenotype

(Lovegrove et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

Simultaneous expression of upd1^Scer\UAS.cZa, ems^Scer\UAS.cSa, ct^Scer\UAS.cLa and grn^Scer\UAS.cBa, under the control of Scer\GAL4^69B allows formation of spiracle-like tubular structures in Abd-B^M1/Abd-B^M1 embryos.

(Lovegrove et al., 2006)

Expression of abd-A^{1dB5.Scer\UAS} cannot suppress the absence of genitalia in Abd-B^LDN/Abd-B^M1 female flies, not the presence of a large seventh tergite in both male and female Abd-B^LDN/Abd-B^M1 flies. abd-A^{1dB5.Scer\UAS} expression is driven by the P{GAL4}Abd-B^LDN insertion in the Abd-B^LDN flies.

(de Navas et al., 2006)

The penetrance of the rotated genitalia phenotype seen in Abd-B^M1 males is enhanced if they are also heterozygous for gpp^1A or gpp^61A. The enhancement is stronger if the gpp allele is inherited maternally.

(Shanower et al., 2005)

abd-A^C1 Abd-B^M1 double heterozygous females show a significant increase in the level of monoene cuticular hydrocarbons compared to wild-type females.

(Wicker-Thomas and Jallon, 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Abd-B^Uab-1

(Sanchez-Herrero and Crosby, 1988)

Abd-B^iab9-x23-1

(Sanchez-Herrero and Crosby, 1988)

Abd-B^iab9-tuh-3

(Sanchez-Herrero and Crosby, 1988)

Abd-B^iab9-Tab

(Sanchez-Herrero and Crosby, 1988)

Abd-B^iab8-D15

(Sanchez-Herrero and Crosby, 1988)

Abd-B^iab8-D14

(Sanchez-Herrero and Crosby, 1988)

Abd-B^iab8-D6

(Sanchez-Herrero and Crosby, 1988)

Abd-B^iab8-rv82

(Sanchez-Herrero and Crosby, 1988)

Abd-B^iab8-rv96

(Sanchez-Herrero and Crosby, 1988)

Abd-B^iab8-rv111

(Sanchez-Herrero and Crosby, 1988)

Abd-B^iab8-rv185

(Sanchez-Herrero and Crosby, 1988)

Abd-B^iab8-rv100

(Sanchez-Herrero and Crosby, 1988)

Abd-B^iab8-rv114

(Sanchez-Herrero and Crosby, 1988)

Abd-B^iab8-rv89

(Sanchez-Herrero and Crosby, 1988)

Abd-B^iab8-rv175

(Sanchez-Herrero and Crosby, 1988)

Abd-B^iab8-rv107

(Sanchez-Herrero and Crosby, 1988)

Abd-B^M9

(Sanchez-Herrero and Crosby, 1988)

Abd-B^M7

(Sanchez-Herrero and Crosby, 1988)

Abd-B^M4

(Sanchez-Herrero and Crosby, 1988)

Abd-B^M2

(Sanchez-Herrero and Crosby, 1988)

Abd-B³⁸⁰

(Sanchez-Herrero and Crosby, 1988)

Abd-B^S2

(Sanchez-Herrero and Crosby, 1988)

Abd-B^S1

(Sanchez-Herrero and Crosby, 1988)

Abd-B^M6

(Sanchez-Herrero and Crosby, 1988)

Abd-B^M5

(Sanchez-Herrero and Crosby, 1988)

Abd-B^M3

(Sanchez-Herrero and Crosby, 1988)

Abd-B^S9

(Sanchez-Herrero and Crosby, 1988)

Abd-B^S8

(Sanchez-Herrero and Crosby, 1988)

Abd-B^S5

(Sanchez-Herrero and Crosby, 1988)

Abd-B^R

(Sanchez-Herrero and Crosby, 1988)

Abd-B^F

(Sanchez-Herrero and Crosby, 1988)

Rescued by

Abd-B^MD761/Abd-B^M1 is rescued by Abd-B^UAS.cCa/Scer\GAL4^Abd-B-MD761

(Curt et al., 2025)

Abd-B^M1/Abd-B^LDN is rescued by Abd-B^UAS.cCa/Scer\GAL4^Abd-B-LDN

(de Navas et al., 2006)

Partially rescued by

Abd-B^M1/Abd-B^LDN is partially rescued by Abd-B^Cter.UAS/Scer\GAL4^Abd-B-LDN

(Curt et al., 2025)

Abd-B^M1/Abd-B^LDN is partially rescued by Abd-B^KK.UAS/Scer\GAL4^Abd-B-LDN

(Curt et al., 2025)

Abd-B^M1/Abd-B^LDN is partially rescued by Abd-B^TG.UAS/Scer\GAL4^Abd-B-LDN

(Curt et al., 2025)

Abd-B^M1/Abd-B^LDN is partially rescued by Abd-B^W.UAS/Scer\GAL4^Abd-B-LDN

(Curt et al., 2025)

Abd-B^MD761/Abd-B^M1 is partially rescued by Scer\GAL4^Abd-B-MD761/Abd-B^CEN.UAS

(Curt et al., 2025)

Abd-B^MD761/Abd-B^M1 is partially rescued by Abd-B^Cter.UAS/Scer\GAL4^Abd-B-MD761

(Curt et al., 2025)

Abd-B^MD761/Abd-B^M1 is partially rescued by Scer\GAL4^Abd-B-MD761/Abd-B^EWTG.UAS

(Curt et al., 2025)

Abd-B^MD761/Abd-B^M1 is partially rescued by Abd-B^KK.UAS/Scer\GAL4^Abd-B-MD761

(Curt et al., 2025)

Abd-B^MD761/Abd-B^M1 is partially rescued by Scer\GAL4^Abd-B-MD761/Abd-B^S.UAS

(Curt et al., 2025)

Abd-B^MD761/Abd-B^M1 is partially rescued by Scer\GAL4^Abd-B-MD761/Abd-B^TG.UAS

(Curt et al., 2025)

Abd-B^MD761/Abd-B^M1 is partially rescued by Scer\GAL4^Abd-B-MD761/Abd-B^UAS.cUa

(Curt et al., 2025)

Abd-B^MD761/Abd-B^M1 is partially rescued by Scer\GAL4^Abd-B-MD761/Abd-B^UAS.m

(Curt et al., 2025)

Abd-B^MD761/Abd-B^M1 is partially rescued by Abd-B^W.UAS/Scer\GAL4^Abd-B-MD761

(Curt et al., 2025)

Abd-B^MD761/Abd-B^M1 is partially rescued by Abd-B^YPWM.UAS/Scer\GAL4^Abd-B-MD761

(Curt et al., 2025)

Not rescued by

Abd-B^M1/Abd-B^LDN is not rescued by Abd-B^CEN.UAS/Scer\GAL4^Abd-B-LDN

(Curt et al., 2025)

Abd-B^M1/Abd-B^LDN is not rescued by Abd-B^EWTG.UAS/Scer\GAL4^Abd-B-LDN

(Curt et al., 2025)

Abd-B^M1/Abd-B^LDN is not rescued by Abd-B^S.UAS/Scer\GAL4^Abd-B-LDN

(Curt et al., 2025)

Abd-B^M1/Abd-B^LDN is not rescued by Abd-B^UAS.cUa/Scer\GAL4^Abd-B-LDN

(Curt et al., 2025)

Abd-B^M1/Abd-B^LDN is not rescued by Abd-B^YPWM.UAS/Scer\GAL4^Abd-B-LDN

(Curt et al., 2025)

Comments

Fails to complement all mutations in the Abd-B domain.

(Sanchez-Herrero and Crosby, 1988)

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

102110

mwh¹ jv¹ st¹ red¹ Sb^sbd-2 e¹¹ ro¹ ca¹ Abd-B^M1 / TM6B, Antp^Hu e¹ Tb¹ ca¹

Notes on Origin

Discoverer

Morata.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Abd-B-M¹

(Bakshi et al., 2020)

Abd-B^M1

(Curt et al., 2025, Molina-Gil et al., 2023, Pinto et al., 2022, Romero-Pozuelo et al., 2019, Sánchez-Higueras et al., 2019, Moris-Sanz et al., 2015, Pinto et al., 2015, Rivas et al., 2013, Sotillos et al., 2013, Foronda et al., 2012, Ho et al., 2011, Zhai et al., 2011, Karlsson et al., 2010, Zhai et al., 2009, Krattinger et al., 2007, de Navas et al., 2006, Lovegrove et al., 2006)

Abd-B^m1

(Bate, 1993, de Lorenzi and Bienz, 1990)

AbdB^M1

(Ghosh et al., 2019, Matsuda et al., 2015, Tsikala et al., 2014, Estacio-Gómez et al., 2013, Merabet et al., 2002)

Name Synonyms

Secondary FlyBase IDs

References (55)

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