FlyBase Allele Report: Dmel\Abd-B[Uab-1]

General Information

Symbol

Dmel\Abd-B^Uab-1

Species

D. melanogaster

Name

FlyBase ID

FBal0000149

Feature type

allele

Associated gene

Dmel\Abd-B

Associated Insertion(s)

Carried in Construct

Also Known As

Uab¹, Uab

Key Links

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Celniker et al., 1990)

Mutagen

ethyl methanesulfonate

(Kuhn et al., 1993, Karch et al., 1985)

Progenitor genotype

Caused by aberration

In(3R)iab9^Uab1

Cytology

Polytene chromosomes normal.

(Kuhn et al., 1993, Karch et al., 1985)

Description

Small inversion.

(Kuhn et al., 1995)

Cytologically normal inversion with breakpoints at coordinates -14kb and 185kb.

(Kuhn et al., 1993)

Breakpoints in the 'bxd' and Abd-B(r) transcription units (FBrf0042053). The abd-A and Abd-B transcription units are inverted with respect to Ubx.

(Sanchez-Herrero, 1991)

-14 kb; +185 kb inverted.

(Karch et al., 1985)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Abd-B is ectopically expressed strongly in single cells or in small patches of cells in the epidermis and the ventral nerve cord in abdominal segments 1-4. Patches of strongly expressing cells are also visible in the normal Abd-B expression domain and are particularly conspicuous in parasegments 10 and 11 which normally express Abd-B weakly.

(Sanchez-Herrero, 1991)

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult abdominal segment 1

adult antennal segment | ectopic | somatic clone

(Foronda et al., 2006)

embryonic abdominal segment 5 (with Abd-B^iab8-D14)

(Chen et al., 2005)

embryonic abdominal segment 6 (with Abd-B^iab8-D14)

(Chen et al., 2005)

embryonic abdominal segment 7 (with Abd-B^iab8-D14)

(Chen et al., 2005)

embryonic abdominal segment 8 (with Abd-B^iab8-D14)

(Chen et al., 2005)

embryonic abdominal segment 9

(Chen et al., 2005, Sanchez-Herrero and Crosby, 1988)

embryonic abdominal segment 9 (with Abd-B^iab8-D14)

(Chen et al., 2005)

female accessory gland (with Abd-B^iab9-x23-1)

(Foronda et al., 2006)

female analia

(Kuhn et al., 1995, Sanchez-Herrero and Crosby, 1988)

female genitalia

(Kuhn et al., 1995, Sanchez-Herrero and Crosby, 1988)

female genitalia (with Abd-B^iab9-x23-1)

(Foronda et al., 2006)

female terminalia

(Kuhn et al., 1993)

genital disc primordium

(Chen et al., 2005)

genital disc primordium (with Abd-B^iab8-D14)

(Chen et al., 2005)

genital disc primordium (with Abd-B^M1)

(Foronda et al., 2006)

genitalia

(Kuhn et al., 1993)

genitalia | somatic clone

(Foronda et al., 2006)

head

(Kuhn et al., 1993)

leg

(Mathog, 1991)

leg | ectopic | somatic clone

(Foronda et al., 2006)

male analia

(Kuhn et al., 1995, Sanchez-Herrero and Crosby, 1988)

male genitalia

(Kuhn et al., 1995, Sanchez-Herrero and Crosby, 1988)

male genitalia (with Abd-B^iab9-x23-1)

(Foronda et al., 2006)

male terminalia

(Kuhn et al., 1993)

parasegment 14

(Sanchez-Herrero and Crosby, 1988)

spermatheca | ectopic (with Abd-B^iab9-x23-1)

(Foronda et al., 2006)

Detailed Description

Statement

Reference

In Abd-B^M1/Abd-B^Uab-1 embryos, the genital disc primordium is disorganised and contains about eight cells. Abd-B^Uab-1 mitotic recombination clones induced in the larval stages exhibit normal analia in both sexes and in the external female structure. In the main genitalia, there are two types of clone: some of them, probably induced in the internal genitalia, transform genital structures into distal leg or, less frequently, antenna. By contrast, clones in the lateral plates or clasper teeth are wild-type or cause only slight pattern alterations. Clones induced in the male A9 segment have smooth borders and are located mostly in the penis apparatus presumptive region. Clones in other regions are, in general, indented. Abd-B^iab9-x23-1/Abd-B^Uab-1 male flies lack internal genitalia, while female genitalia is abnormal. A common feature of these females is the absence of parovaria, and in about half of these, three or even four spermathecae instead of the normal two are observed. Supernumerary spermathecae are also detected in Abd-B^iab9-x23-1/Abd-B^Uab-1 clones. In a few females, duplications of part of the internal genitalia are observed.

(Foronda et al., 2006)

In stage 15 Abd-B^Uab-1 embryos, segment A9 is transformed to an A8-like segment. Abd-B^Uab-1 embryos have the same number of genital disc precursor cells as wild-type embryos, but these cells are aberrantly arranged into two rows, with a gap in the middle, that are connected at their lateral tips. In Abd-B^iab8-D14/Abd-B^Uab-1 mutant embryos, segments A5 to A9 are transformed into more anterior-like segments and most genital disc precursor cells are missing, leaving just ~7 present instead of the wild-type number of 22.

(Chen et al., 2005)

Male and female abdominal segment are normal, genitalia and analia are missing.

(Kuhn et al., 1995)

Adult homozygous males have 6 normal abdominal segments. Males and females lack genitalia. Enhances penetrance of head defect phenotype when in trans with Abd-B^iab9-tuh-3. Heterozygotes with Abd-B^iab9-tuh-3 exhibit genital defects to a moderate degree.

(Kuhn et al., 1993)

The Abd-B^Uab-1 leg transformation is epistatic to the Ubx^bxd-51j transformation.

(Mathog, 1991)

Male and female genitalia and analia are missing or abnormal in homozygotes. Parasegment 14 is partially transformed into parasegment 13, and there is a rudimentary setal belt in A9 in homozygous embryos. Also shows dominant gain-of-function phenotypes.

(Sanchez-Herrero and Crosby, 1988)

Causes A1 to transform toward A2.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Abd-B^Uab-1, ph-d¹ has lethal phenotype

(Dura et al., 1985)

Abd-B^Uab-1, ph-d² has lethal phenotype

(Dura et al., 1985)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

Abd-B^iab8-D15

(Sanchez-Herrero and Crosby, 1988)

Abd-B^iab8-D14

(Sanchez-Herrero and Crosby, 1988)

Abd-B^iab8-D6

(Sanchez-Herrero and Crosby, 1988)

Abd-B^iab8-rv82

(Sanchez-Herrero and Crosby, 1988)

Abd-B^iab8-rv89

(Sanchez-Herrero and Crosby, 1988)

Abd-B^M9

(Sanchez-Herrero and Crosby, 1988)

Abd-B^M7

(Sanchez-Herrero and Crosby, 1988)

Abd-B^M4

(Sanchez-Herrero and Crosby, 1988)

Abd-B^M2

(Sanchez-Herrero and Crosby, 1988)

Abd-B³⁸⁰

(Sanchez-Herrero and Crosby, 1988)

Abd-B^S2

(Sanchez-Herrero and Crosby, 1988)

Abd-B^S1

(Sanchez-Herrero and Crosby, 1988)

Abd-B^M6

(Sanchez-Herrero and Crosby, 1988)

Abd-B^M5

(Sanchez-Herrero and Crosby, 1988)

Abd-B^M3

(Sanchez-Herrero and Crosby, 1988)

Abd-B^S9

(Sanchez-Herrero and Crosby, 1988)

Abd-B^S8

(Sanchez-Herrero and Crosby, 1988)

Abd-B^S5

(Sanchez-Herrero and Crosby, 1988)

Abd-B^R

(Sanchez-Herrero and Crosby, 1988)

Abd-B^F

(Sanchez-Herrero and Crosby, 1988)

Comments

Complements iab-5 and iab-6 alleles.

(Sanchez-Herrero and Crosby, 1988)

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

305

Ubx^bx-3 Abd-B^Uab-1/T(2;3)ap^Xa, ap^Xa

Kyoto

105847

Ubx^bx-3 Abd-B^Uab-1/T(2;3)ap^Xa, ap^Xa

Notes on Origin

Discoverer

Lewis.

E. B. Lewis.

(Karch et al., 1985)

Comments

Reversion studies show that Abd-B^Uab-1 causes abnormal expression of abd-A domain functions in A1.

m⁺ r^- mutant.

(Kuhn et al., 1993)

Abd-B m⁺r^- mutation.

(Kuhn et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

ABD-BII

(Chen et al., 2005)

Abd-B^Uab-1

Abd-B^Uab1

(Foronda et al., 2006)

Abd-B^iab9-Uab1

Uab

(Celniker et al., 1989, Dura et al., 1985)

Uab1

Uab¹

(Chen et al., 2005, Packert and Kuhn, 2003, Bender and Fitzgerald, 2002, Lloyd, 2000, Kuhn et al., 1995, Kuhn et al., 1993, Mathog, 1991, de Lorenzi et al., 1988, Karch et al., 1985, Duncan, 1982)

iab-8^Uab1

(Sanchez-Herrero and Crosby, 1988)

iab9^Uab1

(Mack et al., 1997)

Name Synonyms

Secondary FlyBase IDs

FBal0000143

References (24)

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