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General Information
Symbol
Dmel\Abd-BM8
Species
D. melanogaster
Name
FlyBase ID
FBal0033319
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
AbdBM8
Key Links
Mutagen
    Nature of the Allele
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Mutations within coding region: eliminates m and r function.

    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In

    denticle & embryonic abdominal segment 9 | somatic clone

    sclerite & abdominal segment 8 & embryo | somatic clone

    Detailed Description
    Statement
    Reference

    Mutants lack posterior spiracles but form a well developed A8 ventral denticle belt.

    UbxMX12 abd-AM1 Abd-BM8 triple mutant embryos exhibit a normal head and anterior thorax, but the third thoracic segment and all the abdominal segments are transformed into the second thoracic segment. Embryos also develop a pair of sclerotic plates in the posterior part of the A8 segment. Heat activation of abd-Ahs.PS transforms the cephalic, thoracic and first abdominal segment into A2-A6 identity. The posterior abdomen exhibits transformation of A8 to the A2-A6 identity and presence of an extra belt in A9.

    The second thoracic to the seventh abdominal segment develop as a composite of compartments from two segments. The identity of the eighth abdominal segment is complex: the anterior has characteristics of prothoracic and mesothoracic segments and the posterior may be cephalic. Abd-B- embryos have an abnormal pattern of Dll expression at the extended germ band stage: Keilin's organs develop in the abdominal segments due to ectopic expression of Dll.

    A5-A8 (including female genitalia) transformed to A4 in mosaics. Embryos have sclerotic plates in pA8 and occasional extra denticles in A9, and parasegments 10-13 are transformed to parasegment 9.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    AntpNs-rvC3 ScrC1 abd-AM1 Abd-BM8 quadruple mutant embryos secrete cuticle which has a reiteration of the A1 segment throughout the abdomen. If these embryos are also mutant for hthC1 the abdominal segments all resemble the third abdominal segment.

    Quintuple ScrC1, AntpNs-rvC3, UbxMX2, abd-AM1, Abd-BM8 homozygous larvae (deficient for activity of thoracic and abdominal homeotic genes) exhibit sclerotic plates (sp) anterior to each denticle belt. Expression of Dfdhs.PK, labhs.PH or Ubxhs.PG suppresses the differentiation of the sp.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments

    Fails to complement all mutations in the Abd-B domain.

    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (3)
    Reported As
    Name Synonyms
    Secondary FlyBase IDs
      References (28)