FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Abd-BM5
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General Information
Symbol
Dmel\Abd-BM5
Species
D. melanogaster
Name
FlyBase ID
FBal0033317
Feature type
allele
Associated gene
Dmel\Abd-B
Associated Insertion(s)
Carried in Construct
Also Known As
AbdBM5
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Celniker et al., 1990, de Lorenzi and Bienz, 1990)
Mutagen
ethyl methanesulfonate
(de Lorenzi and Bienz, 1990, Sanchez-Herrero et al., 1985)
Progenitor genotype
Cytology

Polytene chromosomes normal.

(Hendrickson and Sakonju, 1995)
Description

Amino acid replacement: ?119term.

(Foronda et al., 2006)

Nucleotide substitution: C?T.

(Foronda et al., 2006)

Stop codon in first class A exon.

(Hendrickson and Sakonju, 1995)

Mutations within coding region: eliminate m function.

(de Lorenzi and Bienz, 1990)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:16,932,677..16,932,677 [-]
Nucleotide change:

C16932677T

Amino acid change:

Q119term | Abd-B-PB; Q119term | Abd-B-PH

Reported amino acid change:

?119term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. The amino acid substitution to a stop codon produces an Abd-B M protein of 118 amino acids instead of the normal 493.

(Foronda et al., 2006, Hendrickson and Sakonju, 1995, Sanchez-Herrero, 1991, de Lorenzi and Bienz, 1990, Sanchez-Herrero et al., 1985)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      abdominal segment 5

      (Sanchez-Herrero and Crosby, 1988)

      abdominal segment 6

      (Sanchez-Herrero and Crosby, 1988)

      abdominal segment 7

      (Sanchez-Herrero and Crosby, 1988)

      abdominal segment 8

      (Sanchez-Herrero and Crosby, 1988)

      abdominal sternite | ectopic | somatic clone

      (Foronda et al., 2006)

      abdominal tergite 8 | somatic clone

      (Foronda et al., 2006)

      dMP2 neuron | embryonic stage 17 (with Abd-BM2)

      (Miguel-Aliaga and Thor, 2004)

      dMP2 neuron | embryonic stage 17 (with Abd-BM2), with Abd-BUAS.cCa, Scer\GAL4elav-C155

      (Miguel-Aliaga and Thor, 2004)

      embryonic/larval posterior spiracle

      (Castelli-Gair, 1998)

      embryonic abdominal segment 6 (with Df(3R)P115)

      (Lohmann et al., 2002)

      embryonic abdominal segment 7 (with Df(3R)P115)

      (Lohmann et al., 2002)

      embryonic abdominal segment 8 (with Df(3R)P115)

      (Lohmann et al., 2002)

      female genitalia | somatic clone

      (Foronda et al., 2006)

      genital disc primordium

      (Foronda et al., 2006)

      genitalia | female

      (Sanchez-Herrero and Crosby, 1988)

      gonadal sheath proper primordium

      (DeFalco et al., 2004)

      gonadal sheath proper primordium | male

      (DeFalco et al., 2004)

      larval MP1 neuron | embryonic stage 17 (with Abd-BM2)

      (Miguel-Aliaga and Thor, 2004)

      larval MP1 neuron | embryonic stage 17 (with Abd-BM2), with Abd-BUAS.cCa, Scer\GAL4elav-C155

      (Miguel-Aliaga and Thor, 2004)

      parasegment 10

      (Sanchez-Herrero et al., 1994, Sanchez-Herrero, 1991, Sanchez-Herrero and Crosby, 1988)

      parasegment 11

      (Sanchez-Herrero et al., 1994, Sanchez-Herrero, 1991, Sanchez-Herrero and Crosby, 1988)

      parasegment 12

      (Sanchez-Herrero et al., 1994, Sanchez-Herrero, 1991, Sanchez-Herrero and Crosby, 1988)

      parasegment 13

      (Sanchez-Herrero et al., 1994, Sanchez-Herrero, 1991, Sanchez-Herrero and Crosby, 1988)
      Detailed Description
      Statement
      Reference

      The genital primordium in Abd-BM5 homozygous embryos lacks about four hdc-expressing cells, two in each of the two anterior clusters. Abd-BM5 female mutant clones exhibit transformation of the dorsal eighth tergite into an anterior tergite, while the genitalia structures are transformed to varying degrees into a structure resembling a sternite.

      (Foronda et al., 2006)

      Normal numbers of the non-sexually dimorphic somatic gonadal precursor cells (SGPs) are specified in mutant embryos and they associate with the migrating germ cells. However, the gonads are often not as tightly compacted as in wild type. Gonads of mutant male embryos lack male-specific SGPs (which are present in wild-type male embryos) and resemble female gonads.

      (DeFalco et al., 2004)

      dMP2 and MP1 neurons appear to be generated throughout the ventral nerve cord in normal numbers in Abd-BM2/Abd-BM5 embryos. However, at stage 17, all dMP2 and MP1 neurons (including posterior ones) appear to undergo apoptosis (in wild-type embryos, the anterior dMP2 and MP1 neurons are lost by the late embryonic stage, but posterior dMP2 and MP1 neurons persist). Expression of Abd-BScer\UAS.cCa under the control of Scer\GAL4elav-C155 in late stage Abd-BM2/Abd-BM5 embryos results in the suppression of cell death normally seen in anterior dMP2 and MP1 neurons in wild-type late stage embryos.

      (Miguel-Aliaga and Thor, 2004)

      In Abd-BM5/Df(3R)P115 mutant embryos, the boundaries between segments A6 and A7 and between A7 and A8 are partially fused.

      (Lohmann et al., 2002)

      Mutants lack posterior spiracles but form a well developed A8 ventral denticle belt.

      (Castelli-Gair, 1998)

      An A7 segment forms in Abd-BM5/Abd-Biab8-D14 adult males.

      (Castelli-Gair, 1998)

      abd-Ahs.PS Abd-BM5 heat induced embryos exhibit transformation of parasegments 10-13, parasegment 14 is wild type.

      (Sanchez-Herrero et al., 1994)

      Parasegments 10--13 are transformed to parasegment 9 (FBrf0043917).

      (Sanchez-Herrero, 1991)

      A5-A8 are transformed to A4, females lack genitalia, and there is a weak haploinsufficient transformation of A5-A8. Parasegments 10-13 are transformed to parasegment 9 in embryos.

      (Sanchez-Herrero and Crosby, 1988)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      dMP2 and MP1 neurons are generated normally in Abd-BM5 Df(3L)H99 double homozygous embryos. In late stage Abd-BM5 Df(3L)H99 double homozygous embryos neither anterior nor posterior dMP2 and MP1 neurons undergo apoptosis.

      (Miguel-Aliaga and Thor, 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      m-r+, causes abd-A expression to be high in parasegment 13 from the extended germ band stage, with no expression in parasegments 14 or 15.

      (Macias et al., 1990)

      Absence of the 'm' element.

      (Sanchez-Herrero et al., 1994)

      Genetically null for the Abd-B m function.

      (Hendrickson and Sakonju, 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      References (32)