Expression of Abd-BUAS.cCa under the control of Scer\GAL4insc-Mz1407 from mid third instar stage, in combination with a Gal80[ts] transgene, results in a reduced number of neuroblasts in the thoracic segments of the late third instar (male or female) larval ventral nerve cord, compared to controls.
The adulthood-only expression of Abd-BUAS.cCa (using Gal80[ts]) driven by Scer\GAL4C587, but not by Scer\GAL4VP16.nos.UTR or Scer\GAL4hh-Gal4, leads to adult testes exhibiting a significant increase in the number of cyst stem cells (and their localization away from the hub), a reciprocal decrease in the number of differentiated cyst cells, an increase in the number of early stage germline cells, and a strong increase in the number of DNA replicating cells at the apical testis tip (even away from the hub), as compared to controls. This Scer\GAL4C587-dependent expression also leads to a cell non-autonomous induction of both somatic (Zfh1) and germline (Vasa) lineage markers in some somatic-derived cells, as compared to controls.
Embryos expressing Abd-BScer\UAS.cCa under the control of Scer\GAL4twi.PB form ectopic clusters of male-specific somatic gonadal precursor (msSGP) cells in more anterior regions of the embryo than normal. Gonads do not form in these embryos and germ cells are either scattered or associated with msSGPs.
Expression of Abd-BScer\UAS.cCa under the control of Scer\GAL4sca-537.4 results in a mutant phenotype in the embryonic tritocerebrum. The phenotype has a penetrance of more than 95%.
Expression of Abd-BScer\UAS.cCa in the mesoderm under the control of Scer\GAL4unspecified results in severe defects in muscle development; the skeletal muscle pattern is massively deranged and there appear to be no dorsal vessel cells (based upon staining for Mhc expression).
Expression of Abd-BScer\UAS.cCa under the control of Scer\GAL4lab.PH does not result in morphological defects in the tritocerebrum or any other part of the embryonic brain.
Scer\GAL469B-mediated expression in wild type causes a pair of posterior spiracles to develop in all trunk segments.
Scer\GAL4E132 induced expression in the eye-antennal disc causes transformation of the antenna into leg. Scer\GAL4Bx-MS1096 or Scer\GAL4C-765 induced expression in the wing disc causes transformation of the wing into haltere-like tissue. Scer\GAL4C-765 induced expression also causes malformed notum, fused scutellum and disorganised pattern of bristles. Scer\GAL4c739 and Scer\GAL4C-765 induced expression in the abdomen transforms A1 into a posterior abdominal segment.
Scer\GAL4twi.PG induced expression blocks the formation of the gonad primordium.