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Citation
Zhang, S., Pan, C., Lv, X., Wu, W., Chen, H., Wu, W., Wu, H., Zhang, L., Zhao, Y. (2017). Repression of Abd-B by Polycomb is critical for cell identity maintenance in adult Drosophila testis.  Sci. Rep. 7(1): 5101.
FlyBase ID
FBrf0236102
Publication Type
Research paper
Abstract

Hox genes play a fundamental role in regulating animal development. However, less is known about their functions on homeostasis maintenance in adult stem cells. Here, we report that the repression of an important axial Hox gene, Abdominal-B (Abd-B), in cyst stem cells (CySCs) is essential for the homeostasis and cell identity maintenance in the adult Drosophila testis. Derepression of Abd-B in CySCs disrupts the proper self-renewal of both germline stem cells (GSCs) and CySCs, and leads to an excessive expansion of early stage somatic cells, which originate from both lineages. We further demonstrate that canonical Polycomb (Pc) and functional pathway of Polycomb group (PcG) proteins are responsible for maintaining the germline cell identity non-autonomously via repressing Abd-B in CySCs in the adult Drosophila testis.

PubMed ID
PubMed Central ID
PMC5506049 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Sci. Rep.
    Title
    Scientific reports
    ISBN/ISSN
    2045-2322
    Data From Reference