FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\PcΔ69-70.UAS
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General Information
Symbol
Dmel\PcΔ69-70.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0328148
Feature type
allele
Associated gene
Dmel\Pc
Associated Insertion(s)
Carried in Construct
P{UAS-Pc.Δ69-70}
Also Known As
UAS-PcΔ69-70
Key Links
Transgenic product class
dominant_negative_variant
(Lv et al., 2016)
inframe_deletion
(Lv et al., 2016)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Lv et al., 2016)
inframe_deletion
(Lv et al., 2016)
Mutagen
in vitro construct
(Lv et al., 2016)
Progenitor genotype
Carried in construct
P{UAS-Pc.Δ69-70}
Cytology
Description

UAS regulatory sequences drive expression of Pc lacking amino acids 69-70 (resulting in inability to recognize H3K27me3).

(Zhang et al., 2017)

UASt regulatory sequences drive expression of a Pc cDNA, mutated so that amino acids 69-70 are missing.

(Lv et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Pc
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The adulthood-only expression of PcΔ69-70.UAS under the control of Scer\GAL4C587 and Gal80[ts] leads to adult testes exhibiting significant increases in the numbers of cyst stem cells and of early stage germline cells, as compared to controls.

      (Zhang et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      PcΔ69-70.Scer\UAS
      PcΔ69-70.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (3)