FlyBase Allele Report: Dmel\wg[HMS00794]

General Information

Symbol

Dmel\wg^HMS00794

Species

D. melanogaster

Name

FlyBase ID

FBal0257475

Feature type

allele

Associated gene

Dmel\wg

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00794}

Also Known As

Wg RNAi, UAS-wg^RNAi, UAS-wg-RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00794}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00794

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of obesity

CEA

(Lee et al., 2014)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates cancer

modeled by yki^{S111A.S168A.S250A.UAS.Tag:V5}

(Lee et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expressing wg^HMS00794 under the control of Scer\GAL4^R42A07.-FRT leads to loss of the margin around the entire wing.

(Harris et al., 2020)

Adults expressing wg^HMS00794 under the control of Scer\GAL4^Mef2.PR have an increased abdominal fat body with larger lipid droplets than controls.

(Lee et al., 2014)

Expression of wg^HMS00794 under the control of Scer\GAL4^futsch-C380 suppresses the increase in "ghost bouton" number (axon terminal extensions with synaptic vesicles but lacking active zones and postsynaptic structures) per neuromuscular junction caused by spaced high K[+] depolarization.

(Nesler et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Scer\GAL4^R42A07.-FRT/wg^HMS00794 is an enhancer of visible | adult stage | somatic clone phenotype of Ecol\lexA^DBD.R85E08, Hsap\RELA^AD.Hsp70, egr^{13xlexAop.cHa}

(Harris et al., 2020)

Scer\GAL4^R42A07.-FRT/wg^HMS00794 is an enhancer of decreased size | adult stage | somatic clone phenotype of Ecol\lexA^DBD.R85E08, Hsap\RELA^AD.Hsp70, egr^{13xlexAop.cHa}

(Harris et al., 2020)

NOT Enhancer of

Statement

Reference

Scer\GAL4^insc-Mz1407/wg^HMS00794 is a non-enhancer of increased cell number | larval stage phenotype of Vps35^E42

(Li et al., 2018)

Scer\GAL4^insc-Mz1407/wg^HMS00794 is a non-enhancer of abnormal neuroanatomy | larval stage phenotype of Vps35^E42

(Li et al., 2018)

Suppressor of

Statement

Reference

Scer\GAL4^en-e16E/wg^HMS00794 is a suppressor of increased occurrence of cell division phenotype of Scer\GAL4^en-e16E, zip^DN.UAS.GFP

(Verma et al., 2025)

wg^HMS00794, Scer\GAL4^e22c is a suppressor of increased size | larval stage phenotype of BacA\p35^UAS.cHa, Bub3^GD9924, Scer\GAL4^e22c

(Romão et al., 2021)

wg^HMS00794, Scer\GAL4^C587 is a suppressor | partially of increased cell number | spermatogenesis phenotype of Pc^NIG.32443R, Scer\GAL4^C587

(Zhang et al., 2017)

NOT Suppressor of

Statement

Reference

wg^HMS00794, Scer\GAL4^ap-md544 is a non-suppressor of abnormal developmental rate phenotype of BacA\p35^UAS.cHa, Bub3^GD9924, Scer\GAL4^ap-md544

(Romão et al., 2021)

Scer\GAL4^insc-Mz1407/wg^HMS00794 is a non-suppressor of increased cell number | larval stage phenotype of Vps35^E42

(Li et al., 2018)

Scer\GAL4^insc-Mz1407/wg^HMS00794 is a non-suppressor of abnormal neuroanatomy | larval stage phenotype of Vps35^E42

(Li et al., 2018)

Phenotype Manifest In

Enhancer of

Statement

Reference

Scer\GAL4^R42A07.-FRT/wg^HMS00794 is an enhancer of wing | somatic clone phenotype of Ecol\lexA^DBD.R85E08, Hsap\RELA^AD.Hsp70, egr^{13xlexAop.cHa}

(Harris et al., 2020)

NOT Enhancer of

Statement

Reference

Scer\GAL4^insc-Mz1407/wg^HMS00794 is a non-enhancer of larval neuroblast | larval stage | increased number phenotype of Vps35^E42

(Li et al., 2018)

Suppressor of

Statement

Reference

Scer\GAL4^en-e16E/wg^HMS00794 is a suppressor of wing disc posterior compartment phenotype of Scer\GAL4^en-e16E, zip^DN.UAS.GFP

(Verma et al., 2025)

wg^HMS00794, Scer\GAL4^e22c is a suppressor of wing disc | larval stage phenotype of BacA\p35^UAS.cHa, Bub3^GD9924, Scer\GAL4^e22c

(Romão et al., 2021)

Scer\GAL4^insc-Mz1407/wg^HMS00794 is a suppressor of larval brain | larval stage phenotype of Vps35^E42

(Li et al., 2018)

wg^HMS00794, Scer\GAL4^C587 is a suppressor | partially of cyst progenitor cell | spermatogenesis phenotype of Pc^NIG.32443R, Scer\GAL4^C587

(Zhang et al., 2017)

NOT Suppressor of

Statement

Reference

Scer\GAL4^insc-Mz1407/wg^HMS00794 is a non-suppressor of larval neuroblast | increased number | larval stage phenotype of Vps35^E42

(Li et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

The co-expression of wg^HMS00794 marginally suppresses the increased number of cyst stem cells in adult testes resulting from the adulthood-only expression of Pc^NIG.32443R under the control of Scer\GAL4^C587 and Gal80[ts].

(Zhang et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

32994