FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\zipDN.UAS.GFP
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General Information
Symbol
Dmel\zipDN.UAS.GFP
Species
D. melanogaster
Name
FlyBase ID
FBal0190636
Feature type
allele
Associated gene
Dmel\zip
Associated Insertion(s)
Carried in Construct
P{UAS-zip.GFP.DN}
Also Known As
UAS-GFP-DN-zip, DN-zip
Key Links
Transgenic product class
inframe_deletion
(Franke et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Franke et al., 2005)
Mutagen
in vitro construct
(Franke et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-zip.GFP.DN}
Cytology
Description

UASt sequences drive expression of a zip fragment (amino acid residues 775-1972) tagged with GFP at the N terminus.

(Franke et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
zip
Tagged with
GFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flip out clones expressing zipDN.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4GMR.PU have a reduced distance between the apical membranes of rhabdomeres R2 and R4 (width of the retinal lumen) compared to controls.

      (Nie et al., 2014)

      Expression of zipDN.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4pnr-MD237 from 0 hours after puparium formation (APF) (using the temperature sensitive Scer\GAL80ts.αTub84B allele to limit repress expression before this stage) results in bristle orientation defects and epidermal indentations in the notum. Later expression (from 14 hours APF) results in weak bristle orientation defects.

      (Olguín et al., 2011)

      Compared with wild-type flies, those expressing zipDN.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4Cg.PA show a significantly shortened lifespan under starvation conditions.

      (Tang et al., 2011)

      Expression of a single copy of zipDN.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4en-e16E results in variable loss of tissue in the posterior compartment of the wing. Cells in the remaining posterior wing tissue show a multiple wing hair and split hair phenotype.

      Expression of a single copy of zipDN.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4en-e16E in a zip1/+ background results in lethality.

      Expression of two copies of zipDN.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4en-e16E results in lethality.

      Expression of zipDN.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4ap-md544 results in epidermal cells of the thorax having multiple or branched setae. Microchaetae and macrochaetae on the thorax may also show a branched phenotype, or multiple chaetae extending from a single socket cell may also be seen.

      Expression of zipDN.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4ap-md544 results in a complete loss of adhesion between the two epithelial sheets of the wing in nearly all eclosing flies. Only cells along the wing margin are adhered to each other, resulting in wings which appear balloon-like on eclosion and collapse soon afterwards. In addition, the dorsal surface of the wing is reduced in size compared to the ventral surface.

      (Franke et al., 2010)

      Expression of zipDN.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4arm.T:Hsim\VP16 results in the loss of para-segmental boundary straightness.

      (Monier et al., 2010)

      Expression of zipDN.Scer\UAS.T:Avic\GFP, under the control of Scer\GAL4en-e16E, in a zip1/+ background causes stripe misalignments in 52% of embryos, while only 4% of zip1/+ embryos show this phenotype without transgene expression.

      (Franke et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of zipDN.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4GMR.PU enhances the rhabdomere fusion seen in eys1 prom1 double heterozygotes.

      (Nie et al., 2014)

      Co-expression of chasGD7593 and zipDN.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4pnr-MD237 from 14 hours after puparium formation (using the temperature sensitive Scer\GAL80ts.αTub84B allele to limit repress expression before this stage) results in strong bristle orientation defects and epidermal indentations in the notum.

      (Olguín et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      zipDN.UAS.GFP/Scer\GAL4sqh.PW fails to rescue zip2/zip1

      (Franke et al., 2010)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      zipDN.Scer\UAS.T:Avic\GFP
      zipDN.UAS.GFP
      Name Synonyms
      Secondary FlyBase IDs
        References (17)