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General Information
Symbol
Dmel\ScrC1
Species
D. melanogaster
Name
FlyBase ID
FBal0030204
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
    Nature of the Allele
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
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    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    In Ubxhs.PG embryos that are homozygous for ScrC1 the labial sense organ is missing, and there is a duplication of the maxillary sense organ.

    The phenotype of triply mutant clones AntpNs-rvC3 ScrC1 Ubx1 induced at the blastoderm stage or larval stage is the additive phenotype of AntpNs-rvC3 and Scr13A Ubx1 clones, portions of all three legs are transformed to antennae, clones in the haltere and metanotum form wing and mesonotum structures and transformation of labial palps of the proboscis into maxillary palps. The phenotype of AntpNs-rvC3 ScrC1 clones induced in the head, pro- and mesothorax during embryonic and larval development are indistinguishable from AntpNs-rvC3 ScrC1 Ubx1 clones.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Suppressed by
    NOT suppressed by
    Other
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    The number of LinA-derived neurons is dramatically reduced compared to wild type in ScrC1 AntpNs-rvC3 UbxMX12 triple mutant clones examined at the late third instar larval stage. This phenotype is seen in all three thoracic segments. The number of glia derived from the triple mutant LinA neuroblast clones is also reduced compared to wild type.

    Adult motor neurons derived from ScrC1 AntpNs-rvC3 UbxMX12 triple mutant LinA neuroblast clones target the same region of the leg as do wild-type LinA-derived neurons. However, fewer branches are observed compared with wild-type clones, with the distal region of the tibia being most highly affected.

    Single cell class IV dendrite arborisation (da) neuron clones that are triply mutant for ScrC1, AntpNs-rvC3, UbxMX12 show severe defects in dendrite growth, branching and coverage in segment T3 as well as axon fasciculation defects. Analysis of ScrC1, AntpNs-rvC3, UbxMX12 triple mutant ddaC neuron clones indicates that although the major dendrites of the mutant neurons grow to a similar extent as wild-type controls in the interval between 80 and 96 hours after egg laying, the mutant clones have an increased number of terminal dendrites compared to controls. The mutant clones also show increased dynamic behaviour over this time period compared to controls, due to increased dendrite branch initiation/growth. The number of dendrite retractions is not altered in the mutant neurons.

    ScrC1 AntpNs-rvC3 double mutant embryos develop ectopic sclerites, which often look like the cuticular scar tissue that often surrounds the healed wound generated by a sterile needle in late-stage wild-type embryos.

    ScrC1 AntpNs-rvC3 double mutant stage 17 embryos have failures in epidermal integrity; dye injected into the perivitelline space penetrates the body cavity in the mutant embryos.

    AntpNs-rvC3 hthMeis1-P2 ScrC1 triple mutant clones result in two-segment appendages in T1 and T2.

    AntpNs-rvC3 ScrC1 abd-AM1 Abd-BM8 quadruple mutant embryos secrete cuticle which has a reiteration of the A1 segment throughout the abdomen. If these embryos are also mutant for hthC1 the abdominal segments all resemble the third abdominal segment.

    Quintuple ScrC1, AntpNs-rvC3, UbxMX2, abd-AM1, Abd-BM8 homozygous larvae (deficient for activity of thoracic and abdominal homeotic genes) exhibit sclerotic plates (sp) anterior to each denticle belt. Expression of Dfdhs.PK, labhs.PH or Ubxhs.PG suppresses the differentiation of the sp.

    Xenogenetic Interactions
    Statement
    Reference

    Expression of BacA\p35Scer\UAS.cHa under the simultaneous control of both Scer\GAL4VGlut-OK371 and Scer\GAL4tub.PU rescues the reduced number of LinA-derived neurons seen in ScrC1 AntpNs-rvC3 UbxMX12 triple mutant clones examined at the late third instar larval stage. The reduction in number of glia derived from the triple mutant LinA neuroblast clones is not rescued.

    Expression of BacA\p35Scer\UAS.cHa under the simultaneous control of both Scer\GAL4VGlut-OK371 and Scer\GAL4tub.PU partially rescues the defects seen in adult motor neurons of the leg derived from ScrC1 AntpNs-rvC3 UbxMX12 triple mutant LinA neuroblast clones.

    Complementation and Rescue Data
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    Synonyms and Secondary IDs (2)
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    Secondary FlyBase IDs
      References (21)