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General Information
Symbol
Dmel\UbxMX12
Species
D. melanogaster
Name
FlyBase ID
FBal0030342
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    UbxMX12 abd-AM1 Abd-BM8 triple mutant embryos exhibit a normal head and anterior thorax, but the third thoracic segment and all the abdominal segments are transformed into the second thoracic segment. Embryos also develop a pair of sclerotic plates in the posterior part of the A8 segment. Heat activation of abd-Ahs.PS transforms the cephalic, thoracic and first abdominal segment into A2-A6 identity. The posterior abdomen exhibits transformation of A8 to the A2-A6 identity and presence of an extra belt in A9.

    The second thoracic to the seventh abdominal segment develop as a composite of compartments from two segments. The identity of the eighth abdominal segment is complex: the anterior has characteristics of prothoracic and mesothoracic segments and the posterior may be cephalic. Ubx- embryos have an abnormal pattern of Ba expression at the extended germ band stage: Keilin's organs develop in the abdominal segments due to ectopic expression of Ba.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Suppressed by
    NOT suppressed by
    Other
    Statement
    Reference
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    The number of LinA-derived neurons is dramatically reduced compared to wild type in ScrC1 AntpNs-rvC3 UbxMX12 triple mutant clones examined at the late third instar larval stage. This phenotype is seen in all three thoracic segments. The number of glia derived from the triple mutant LinA neuroblast clones is also reduced compared to wild type.

    Adult motor neurons derived from ScrC1 AntpNs-rvC3 UbxMX12 triple mutant LinA neuroblast clones target the same region of the leg as do wild-type LinA-derived neurons. However, fewer branches are observed compared with wild-type clones, with the distal region of the tibia being most highly affected.

    Single cell class IV dendrite arborisation (da) neuron clones that are triply mutant for ScrC1, AntpNs-rvC3, UbxMX12 show severe defects in dendrite growth, branching and coverage in segment T3 as well as axon fasciculation defects. Analysis of ScrC1, AntpNs-rvC3, UbxMX12 triple mutant ddaC neuron clones indicates that although the major dendrites of the mutant neurons grow to a similar extent as wild-type controls in the interval between 80 and 96 hours after egg laying, the mutant clones have an increased number of terminal dendrites compared to controls. The mutant clones also show increased dynamic behaviour over this time period compared to controls, due to increased dendrite branch initiation/growth. The number of dendrite retractions is not altered in the mutant neurons.

    Xenogenetic Interactions
    Statement
    Reference

    Expression of BacA\p35Scer\UAS.cHa under the simultaneous control of both Scer\GAL4VGlut-OK371 and Scer\GAL4tub.PU rescues the reduced number of LinA-derived neurons seen in ScrC1 AntpNs-rvC3 UbxMX12 triple mutant clones examined at the late third instar larval stage. The reduction in number of glia derived from the triple mutant LinA neuroblast clones is not rescued.

    Expression of BacA\p35Scer\UAS.cHa under the simultaneous control of both Scer\GAL4VGlut-OK371 and Scer\GAL4tub.PU partially rescues the defects seen in adult motor neurons of the leg derived from ScrC1 AntpNs-rvC3 UbxMX12 triple mutant LinA neuroblast clones.

    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (2)
    References (27)