FlyBase Allele Report: Dmel\exd[GD1439]

General Information

Symbol

Dmel\exd^GD1439

Species

D. melanogaster

Name

FlyBase ID

FBal0209533

Feature type

allele

Associated gene

Dmel\exd

Associated Insertion(s)

Carried in Construct

P{GD1439}

Also Known As

UAS-exd^RNAi, UAS-exdRNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD1439}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD1439

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

homeotic | adult stage, with Scer\GAL4^pnr-MD237

(Curt et al., 2025)

lethal | pupal stage, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

lethal - all die during larval stage, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

partially lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

partially lethal, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

partially lethal - majority die | pupal stage, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

visible, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

visible | adult stage, with Scer\GAL4^pnr-MD237

(Curt et al., 2025)

visible | adult stage | female, with Scer\GAL4^Abd-B-LDN

(Curt et al., 2025)

visible | adult stage | male, with Scer\GAL4^Abd-B-MD761

(Curt et al., 2025)

Phenotype Manifest In

adult abdominal segment 6, with Scer\GAL4^pnr-MD237

(Curt et al., 2025)

adult abdominal segment 7 | ectopic | male, with Scer\GAL4^Abd-B-MD761

(Curt et al., 2025)

adult heart, with Scer\GAL4^HCH.Hand

(Neely et al., 2010)

hypogynial tooth | adult stage, with Scer\GAL4^Abd-B-LDN

(Curt et al., 2025)

mesonotum, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

sarcomere, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

trichome | adult stage | ectopic, with Scer\GAL4^pnr-MD237

(Curt et al., 2025)

Z disc, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

Detailed Description

Statement

Reference

Larvae expressing exd^GD1439 under the control of Scer\GAL4^Hml.Δ do not show changes in the number of lymph gland hemocytes, as compared to controls.

(Baril et al., 2017)

Adults expressing exd^GD1439 under the control of the cardioblast-specific Scer\GAL4^tin.CΔ4 driver show significantly reduced survival on day 6 after a shift to 29[o]C compared to control flies.

Adults expressing exd^GD1439 under the control of Scer\GAL4^HCH.Hand show a significant increase in systolic diameter and a significant decrease in fractional shortening compared to controls. Heart period and diastolic diameter are not significantly different from controls.

(Neely et al., 2010)

Adults expressing exd^GD1439 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control of Scer\GAL4^Mef2.PR results in late larval lethality.

Expression under the control of Scer\GAL4^Mef2.PR results in grossly normal larval body wall muscles.

Expression under the control of Scer\GAL4^Mef2.PR results in sarcomeres with discontinuous Z-lines in the larval body wall muscles.

(Schnorrer et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 results in lethality or semi-lethality at the pupal stage, depending on the insertion line used.

Expression under the control of Scer\GAL4^pnr-MD237 results in the absence of 100% of the Scer\GAL4^pnr-MD237-expressing area of the notum.

Expression under the control of Scer\GAL4^pnr-MD237 results in an enlarged notum.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

1439

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Scer\GAL4^Abd-B-MD761, exd^GD1439 has visible | adult stage | male phenotype, non-enhanceable by Scer\GAL4^Abd-B-MD761/hth^GD4741

(Curt et al., 2025)

NOT Enhancer of

Statement

Reference

exd^GD1439, Scer\GAL4^Abd-B-MD761 is a non-enhancer of visible | adult stage | male phenotype of Abd-B^MD761/Abd-B^M1, Abd-B^UAS.m, Scer\GAL4^Abd-B-MD761

(Curt et al., 2025)

NOT Suppressor of

Statement

Reference

exd^GD1439, Scer\GAL4^Abd-B-MD761 is a non-suppressor of visible | male | adult stage phenotype of Abd-B^MD761/Abd-B^M1, Abd-B^UAS.m, Scer\GAL4^Abd-B-MD761

(Curt et al., 2025)

exd^GD1439, Scer\GAL4^Hml.Δ is a non-suppressor of increased cell number | third instar larval stage phenotype of Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Hml.Δ

(Baril et al., 2017)

hth^KK108831/exd^GD1439, Scer\GAL4^Hml.Δ is a non-suppressor of increased cell number | third instar larval stage phenotype of Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Hml.Δ

(Baril et al., 2017)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Scer\GAL4^Abd-B-MD761, exd^GD1439 has adult abdominal segment 7 | ectopic | male phenotype, non-enhanceable by Scer\GAL4^Abd-B-MD761/hth^GD4741

(Curt et al., 2025)

NOT Enhancer of

Statement

Reference

exd^GD1439, Scer\GAL4^Abd-B-MD761 is a non-enhancer of adult abdominal segment 7 | ectopic | male phenotype of Abd-B^MD761/Abd-B^M1, Abd-B^UAS.m, Scer\GAL4^Abd-B-MD761

(Curt et al., 2025)

NOT Suppressor of

Statement

Reference

exd^GD1439, Scer\GAL4^Abd-B-MD761 is a non-suppressor of adult abdominal segment 7 | ectopic | male phenotype of Abd-B^MD761/Abd-B^M1, Abd-B^UAS.m, Scer\GAL4^Abd-B-MD761

(Curt et al., 2025)

exd^GD1439, Scer\GAL4^Hml.Δ is a non-suppressor of embryonic/larval lymph gland | third instar larval stage phenotype of Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Hml.Δ

(Baril et al., 2017)

exd^GD1439, Scer\GAL4^Hml.Δ is a non-suppressor of embryonic/larval hemocyte | third instar larval stage phenotype of Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Hml.Δ

(Baril et al., 2017)

hth^KK108831/exd^GD1439, Scer\GAL4^Hml.Δ is a non-suppressor of embryonic/larval lymph gland | third instar larval stage phenotype of Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Hml.Δ

(Baril et al., 2017)

hth^KK108831/exd^GD1439, Scer\GAL4^Hml.Δ is a non-suppressor of embryonic/larval hemocyte | third instar larval stage phenotype of Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^Hml.Δ

(Baril et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

Larvae co-expressing hth^KK108831 and exd^GD1439 under the control of Scer\GAL4^Hml.Δ do not show changes in the number of lymph gland hemocytes, as compared to controls.

(Baril et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

1439

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

exd^GD1439

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

Open Close