FlyBase Allele Report: Dmel\hth[GD4741]

General Information

Symbol

Dmel\hth^GD4741

Species

D. melanogaster

Name

FlyBase ID

FBal0209704

Feature type

allele

Associated gene

Dmel\hth

Associated Insertion(s)

Carried in Construct

P{GD4741}

Also Known As

UAS-hth-RNAi, hth-RNAi, UAS-hth^RNAi, UAS-hthRNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD4741}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD4741

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult abdominal segment 7 | ectopic | male, with Scer\GAL4^Abd-B-MD761

(Curt et al., 2025)

Detailed Description

Statement

Reference

Expression of hth^GD4741 under the control of Scer\GAL4^ct.CtB does not result in significant changes in the morphology of cells in the third instar Malpighian tubules, as compared to wild type.

(Zohar-Stoopel et al., 2014)

Adults expressing hth^GD4741 under the control of the cardioblast-specific Scer\GAL4^tin.CΔ4 driver show significantly reduced survival on day 6 after a shift to 29[o]C compared to control flies.

(Neely et al., 2010)

Adults expressing hth^GD4741 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Depending on the insertion line used, expression under the control of Scer\GAL4^Mef2.PR can result in early larval lethality or late larval lethality.

Expression under the control of Scer\GAL4^Mef2.PR results in grossly normal larval body wall muscles.

Expression under the control of Scer\GAL4^Mef2.PR results in wild-type sarcomeres in the larval body wall muscles.

(Schnorrer et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 results in lethality or semi-lethality at the pupal stage, depending on the insertion line used.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

4741

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Scer\GAL4^Abd-B-MD761/hth^GD4741 is a non-enhancer of visible | adult stage | male phenotype of Scer\GAL4^Abd-B-MD761, exd^GD1439

(Curt et al., 2025)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Scer\GAL4^Abd-B-MD761/hth^GD4741 is a non-enhancer of adult abdominal segment 7 | ectopic | male phenotype of Scer\GAL4^Abd-B-MD761, exd^GD1439

(Curt et al., 2025)

Additional Comments

Genetic Interactions

Statement

Reference

Mosaic clones expressing hth^GD4741 and yki^Scer\UAS.cHa (under the control of Scer\GAL4^αTub84B.PP) exhibit down-regulation of dm in the notum and do not grow tumors in that region. These clones are indistinguishable from yki^Scer\UAS.cHa clones in the wing pouch region (where hth expression is not detected).

(Ziosi et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

VDRC

v12763