FlyBase Allele Report: Dmel\gpp[X]

General Information

Symbol

Dmel\gpp^X

Species

D. melanogaster

Name

FlyBase ID

FBal0175658

Feature type

allele

Associated gene

Dmel\gpp

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Shanower et al., 2005)

Progenitor genotype

Caused by aberration

In(3R)gpp^X

Cytology

Description

Inversion breakpoint in an intron of gpp.

(Shanower et al., 2005)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Song et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate | larval stage

(Shanower et al., 2005)

lethal (with Df(3R)WIN11)

(Shanower et al., 2005)

lethal (with gpp⁸)

(Shanower et al., 2005)

lethal (with gpp^61A)

(Shanower et al., 2005)

lethal (with gpp⁰³³⁴²)

(Shanower et al., 2005)

lethal (with gpp^IN1)

(Shanower et al., 2005)

lethal (with gpp^XXV)

(Shanower et al., 2005)

lethal - all die before end of larval stage | recessive

(Shanower et al., 2005)

some die during larval stage | recessive

(Shanower et al., 2005)

suppressor of variegation, with P{hsp26-pt-T}39C-50

(Shanower et al., 2005)

suppressor of variegation, with P{hsp26-pt-T}39C-55

(Shanower et al., 2005)

suppressor of variegation, with P{hsp26-pt-T}39C-72

(Shanower et al., 2005)

suppressor of variegation, with P{hsp26-pt-T}Dyrk3^118E-15

(Shanower et al., 2005)

suppressor of variegation | partially, with P{hsp26-pt-T}39C-5

(Shanower et al., 2005)

Phenotype Manifest In

prothoracic tarsal segment 4 | male (with gpp^61A)

(Shanower et al., 2005)

sex comb (with gpp^61A)

(Shanower et al., 2005)

sex comb | ectopic (with gpp^61A)

(Shanower et al., 2005)

Detailed Description

Statement

Reference

Homozygotes are lethal during late larval stages and show no obvious patterning defects. The growth rate of mutant larvae is reduced relative to similarly aged control larvae. Dissected gpp^61A/gpp^X male pupae show a reduction in the number of sex comb teeth and also have sex combs on the fourth tarsal segment of the first leg.

(Shanower et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

gpp[+]/gpp^X is an enhancer of sex comb | ectopic phenotype of Pcl¹⁰

(Shanower et al., 2005)

gpp[+]/gpp^X is an enhancer of sex comb | ectopic phenotype of Scm^D1

(Shanower et al., 2005)

gpp[+]/gpp^X is an enhancer of sex comb | ectopic phenotype of Pc³

(Shanower et al., 2005)

gpp[+]/gpp^X is an enhancer of sex comb | ectopic phenotype of Sce¹

(Shanower et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

gpp^X does not suppress the pairing-sensitive silencing seen in flies carrying P{Mcp-ff#13}101 and P{Mcp-w#14}AP-2^stummelbein in cis or P{Mcp-wy#2}63 and P{Mcp-ff#15}30 in cis, but suppresses the pairing-sensitive silencing seen in flies carrying P{Mcp-w#11}16 and P{Mcp-w#11}102 in cis.

(Shanower et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

gpp^X

(Song et al., 2018, Clough et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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