FlyBase Allele Report: Dmel\Ace[+mFa]

General Information

Symbol

Dmel\Ace^+mFa

Species

D. melanogaster

Name

FlyBase ID

FBal0028716

Feature type

allele

Associated gene

Dmel\Ace

Associated Insertion(s)

Carried in Construct

P{Ace.F}

P{Ace.Fb}

Key Links

Transgenic product class

wild_type

(Fournier et al., 1992)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Fournier et al., 1992)

Mutagen

in vitro construct

(Incardona and Rosenberry, 1996, Fournier et al., 1992)

Progenitor genotype

Carried in construct

P{Ace.F}

P{Ace.Fb}

Cytology

Description

5.8kb Ace minigene consisting of 1.5kb 5' genomic DNA from the Ace region fused to a full length Ace cDNA.

(Incardona and Rosenberry, 1996)

Intronless Ace coding region fused to 1.5 kb of promoter sequences.

(Fournier et al., 1992)

Gene size reduced from 34kb to 5.8 kb. Heat shock terminal sequence ligated to 3' end cDNA.

(Hoffmann et al., 1992)

Allele components

Component

Use(s)

Regulatory region(s)

Ace

Encoded product / tool

Ace

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

chemical resistant

(Fournier et al., 1992)

wild-type

(Incardona and Rosenberry, 1996, Fournier et al., 1992)

Phenotype Manifest In

Detailed Description

Statement

Reference

Abl¹ Nrt^M2 double mutant causes absence of most intersegmental longitudinal axon bundles and most commissural axon bundles. The loss of pros has an additive effect on the mutant phenotype. Loss of Abl function does not detectably alter pros mutant phenotype.

(Incardona and Rosenberry, 1996)

The minigene can successfully rescue Ace^- lethality. In rescued flies all acetylcholinesterase activity is derived from the minigene. They display only 20-25% of wild type activity, and low levels of resistance to malathion.

(Fournier et al., 1992)

Reduced viability with respect to wild type due to low enzyme activity.

(Hoffmann et al., 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement