FlyBase Allele Report: Dmel\Egfr[top-18A]

General Information

Symbol

Dmel\Egfr^top-18A

Species

D. melanogaster

Name

FlyBase ID

FBal0029754

Feature type

allele

Associated gene

Dmel\Egfr

Associated Insertion(s)

Carried in Construct

Also Known As

top^18A, Egfr^top18A

Key Links

Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Price et al., 1989)

loss of function allele

(Weber et al., 2003)

Mutagen

Progenitor genotype

Caused by aberration

Df(2R)Egfr18

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage

(Baker and Rubin, 1992, Price et al., 1989)

some die during embryonic stage

(Baker and Rubin, 1992, Price et al., 1989)

Phenotype Manifest In

eye disc | somatic clone

(Yang and Baker, 2001)

photoreceptor cell R8 | somatic clone

(Yang and Baker, 2001)

Detailed Description

Statement

Reference

The mesoderm is able to spread out over the ectoderm after mesoderm invagination in Egfr^top-18A mutant embryos.

(Wilson et al., 2005)

The number of neuronal cells is reduced in homozygous clones in the eye disc and the number does not increase posterior to the furrow as occurs during normal development. There appears to be a delay in differentiation within the clones. An abnormal pattern of R8 precursor cells, often twinned, is specified, and is not followed by recruitment of any other neuronal cell types, and posterior to the furrow R8 cells disappear.

(Yang and Baker, 2001)

Suppresses the "Ellipse" phenotype.

(Baker and Rubin, 1992)

Behaves phenotypically as a severe point mutation.

(Price et al., 1989)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Egfr[+]/Egfr^top-18A is an enhancer of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, nmo^UAS.cUa

(Mirkovic et al., 2011)

Suppressor of

Statement

Reference

Egfr[+]/Egfr^top-18A is a suppressor of abnormal planar polarity phenotype of fz²¹/fz¹⁹

(Weber et al., 2008)

Phenotype Manifest In

Enhancer of

Statement

Reference

Egfr[+]/Egfr^top-18A is an enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, nmo^UAS.cUa

(Mirkovic et al., 2011)

Egfr[+]/Egfr^top-18A is an enhancer of crossvein | increased number phenotype of Pcyt1^Ala.UAS, Scer\GAL4^sd-SG29.1

(Weber et al., 2003)

Egfr^top-18A is an enhancer of egg chorion phenotype of Ras85D^ix12a

(Schnorr and Berg, 1996)

NOT Enhancer of

Statement

Reference

Egfr[+]/Egfr^top-18A is a non-enhancer of wing phenotype of N^55e11

(Weber et al., 2003)

Suppressor of

Statement

Reference

Egfr[+]/Egfr^top-18A is a suppressor of ommatidium phenotype of fz²¹/fz¹⁹

(Weber et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

Egfr^top-18A/+ enhances the ommatidial over-rotation phenotype which is caused by expression of nmo^Scer\UAS.cUa under the control of Scer\GAL4^hs.2sev.

(Mirkovic et al., 2011)

The symmetrical ommatidium phenotype seen in fz¹⁹/fz²¹ flies is suppressed by Egfr^top-18A/+.

(Weber et al., 2008)

The mesoderm is able to spread out over the ectoderm after mesoderm invagination in Egfr^top-18A sog^Y506 brk^M68 triple mutant embryos.

(Wilson et al., 2005)

The extra crossvein wing phenotype of Cct1^Ala.Scer\UAS mutants is enhanced when Cct1^Ala.Scer\UAS is overexpressed (driven by Scer\GAL4^sd-SG29.1) in Egfr^top-18A/+ flies. The notching seen in wings of N^55e11/+ flies is not enhanced in Egfr^top-18A/+ mutants.

(Weber et al., 2003)

fs(1)K10¹; Egfr^top-18A double mutant females produce eggs with ventralised eggshells and embryos.

(Schnorr and Berg, 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

Egfr^Df

(Schnorr and Berg, 1996)

Egfr^top-18A

(Djiane and Mlodzik, 2010, Rodrigues et al., 2005)

Egfr^top18A

(Mirkovic et al., 2011, Weber et al., 2008, Weber et al., 2003, Greenwood and Struhl, 1999)

egfr^top18A

(Baker et al., 2009, Yang and Baker, 2003)

top-18A

(Weber et al., 2012)

top^18A

(Firth and Baker, 2005, Wilson et al., 2005, Yang and Baker, 2001, Kraut and Campos-Ortega, 1996, Baker and Rubin, 1992, Price et al., 1989)

top^18a

(Schnorr and Berg, 1996)

top^Df18A

(Casci et al., 1999)

Name Synonyms

Secondary FlyBase IDs

References (18)

Report Sections

Open Close