FlyBase Allele Report: Dmel\Ras85D[ix12a]

General Information

Symbol

Dmel\Ras85D^ix12a

Species

D. melanogaster

Name

FlyBase ID

FBal0058375

Feature type

allele

Associated gene

Dmel\Ras85D

Associated Insertion(s)

P{PZ-Δix12a}Ras85D^ix12a

Carried in Construct

Also Known As

Ras1^ix12a

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Wasserman and Freeman, 1998, Schnorr and Berg, 1996)

Mutagen

Delta2-3 transposase

(Schnorr and Berg, 1996)

P-element activity

(Schnorr et al., 2001)

Progenitor genotype

Ras85D⁰⁵⁷⁰³

(Schnorr et al., 2001, Schnorr and Berg, 1996)

Associated Insertion(s)

P{PZ-Δix12a}Ras85D^ix12a

Cytology

Description

Internal deletion of the P{PZ} element, retaining 2kb of the original 15kb transposon.

(Schnorr and Berg, 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Wasserman and Freeman, 1998)

Phenotype Manifest In

dorsal appendage

(Lu and Li, 1999, Wasserman and Freeman, 1998)

dorsal appendage (with Df(3R)by10)

(Schnorr et al., 2001)

egg

(Wasserman and Freeman, 1998)

egg chorion

(Schnorr et al., 2001, Schnorr and Berg, 1996)

Detailed Description

Statement

Reference

Eggs derived from homozygous females lays eggs that range in phenotype from wild type to eggs having a slight expansion of the chorion at the base of the dorsal appendage (more than 70% of dorsal appendages are wild type). Eggs derived from Ras85D^ix12a/Df(3R)by10 females have a single dorsal appendage.

(Schnorr et al., 2001)

94% of eggs laid by Ras85D^e2F/Ras85D^ix12a females have one fused dorsal appendage.

(Lu and Li, 1999)

Small proportion of eggs from homozygous females have fused dorsal appendages.

(Wasserman and Freeman, 1998)

Homozygous and hemizygous (transheterozygotes with Df(3R)by10) females lay eggs that range from wild-type to those exhibiting slightly defective chorion evidenced by close spacing and slight enlargement of the bases of the dorsal appendages.

(Schnorr and Berg, 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Ras85D^ix12a has dorsal appendage phenotype, enhanceable by POSH^k11507/POSH[+]

(Schnorr et al., 2001)

Ras85D^ix12a has dorsal appendage phenotype, enhanceable by P{lacW}Nrk^k14301/+

(Schnorr et al., 2001)

Ras85D^ix12a has dorsal appendage phenotype, enhanceable by S[+]/S^k09312

(Schnorr et al., 2001)

Ras85D^ix12a has dorsal appendage phenotype, enhanceable by Sec61beta[+]/Sec61β^k03307

(Schnorr et al., 2001)

Ras85D^ix12a has dorsal appendage phenotype, enhanceable by Sec61beta[+]/Sec61β^k03316

(Schnorr et al., 2001)

Ras85D^ix12a has dorsal appendage phenotype, enhanceable by Sec61beta[+]/Sec61β^k07819b

(Schnorr et al., 2001)

Ras85D^ix12a has dorsal appendage phenotype, enhanceable by Sec61beta[+]/Sec61β^k16004

(Schnorr et al., 2001)

Ras85D^ix12a has dorsal appendage phenotype, enhanceable by Sec61β^k17010b/Sec61beta[+]

(Schnorr et al., 2001)

Ras85D^ix12a has dorsal appendage phenotype, enhanceable by bs[+]/bs^k07909

(Schnorr et al., 2001)

Ras85D^ix12a has dorsal appendage phenotype, enhanceable by chic[+]/chic⁰⁷⁸⁸⁶

(Schnorr et al., 2001)

Ras85D^ix12a has dorsal appendage phenotype, enhanceable by chic[+]/chic^k13321

(Schnorr et al., 2001)

Ras85D^ix12a has dorsal appendage phenotype, enhanceable by dock[+]/dock⁰⁴⁷²³

(Schnorr et al., 2001)

Ras85D^ix12a has dorsal appendage phenotype, enhanceable by l(2)43Bb[+]/l(2)43Bb^04614a

(Schnorr et al., 2001)

Ras85D^ix12a has dorsal appendage phenotype, enhanceable by pnut[+]/pnut⁰²⁵⁰²

(Schnorr et al., 2001)

Ras85D^ix12a has dorsal appendage phenotype, enhanceable by Sumo⁰⁴⁴⁹³

(Schnorr et al., 2001)

Ras85D^ix12a has dorsal appendage phenotype, enhanceable by Sumo^k01211/smt3[+]

(Schnorr et al., 2001)

Ras85D^ix12a has egg chorion phenotype, enhanceable by Df(2R)Egfr3/+

(Schnorr et al., 2001)

Ras85D^ix12a has egg chorion phenotype, enhanceable by grk³/grk[+]

(Schnorr et al., 2001)

Ras85D^ix12a has dorsal appendage phenotype, enhanceable by Btk29A[+]/Btk^k00206

(Schnorr et al., 2001)

Ras85D^ix12a has dorsal appendage phenotype, enhanceable by Egfr[+]/Egfr^k05115

(Schnorr et al., 2001)

Ras85D^ix12a has dorsal appendage phenotype, enhanceable by MESK2^k05623/MESK2[+]

(Schnorr et al., 2001)

Ras85D^ix12a has dorsal appendage phenotype, enhanceable by spi¹

(Wasserman and Freeman, 1998)

Ras85D^ix12a has egg phenotype, enhanceable by spi¹

(Wasserman and Freeman, 1998)

Ras85D^ix12a has dorsal appendage phenotype, enhanceable by vn¹⁰⁵⁶⁷

(Wasserman and Freeman, 1998)

Ras85D^ix12a has egg phenotype, enhanceable by vn¹⁰⁵⁶⁷

(Wasserman and Freeman, 1998)

Ras85D^ix12a has egg chorion phenotype, enhanceable by Egfr^top-18A

(Schnorr and Berg, 1996)

Ras85D^ix12a has egg chorion phenotype, enhanceable by grk³

(Schnorr and Berg, 1996)

Suppressed by

Statement

Reference

Ras85D^e2F/Ras85D^ix12a has dorsal appendage phenotype, suppressible | partially by Df(2R)nap8/+

(Lu and Li, 1999)

Ras85D^e2F/Ras85D^ix12a has dorsal appendage phenotype, suppressible | partially by Src42A[+]/Src42A^15-1

(Lu and Li, 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Homozygous females that are also heterozygous for Df(2R)Egfr3 or for grk³ show an enhancement of the eggshell phenotype. The P{lacW}Nrk^k14301 insertion (which is inserted into 2 overlapping genes; intron 1 of TppII and exon 1 of Nrk) is a moderate dominant enhancer of the Ras85D^ix12a eggshell phenotype; 31-40% of dorsal appendages are wild type.

(Schnorr et al., 2001)

The fused dorsal appendage phenotype is partially suppressed by one copy of Src42A^15-1 or Df(2R)nap8.

(Lu and Li, 1999)

The proportion of eggs from homozygous females that have fused dorsal appendages is dramatically enhanced by halving spi dosage.

(Wasserman and Freeman, 1998)

Eggshell phenotype is enhanced by mutations in Egfr and grk.

(Schnorr and Berg, 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Ras1^1x12a

(Lu and Li, 1999)

Ras1^ix12a

(Schnorr et al., 2001)

Ras85D^ix12a

ras1^ix12a

(Wasserman and Freeman, 1998)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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