FlyBase Allele Report: Dmel\N[nucl.sev]

General Information

Symbol

Dmel\N^nucl.sev

Species

D. melanogaster

Name

FlyBase ID

FBal0029999

Feature type

allele

Associated gene

Dmel\N

Associated Insertion(s)

Carried in Construct

P{sev-Notch^nucl}

Also Known As

sev-N^nucl

Key Links

Transgenic product class

inframe_deletion

(Fortini et al., 1993)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Fortini et al., 1993)

Mutagen

in vitro construct

(Fortini et al., 1993)

Progenitor genotype

Carried in construct

P{sev-Notch^nucl}

Cytology

Description

Construct: N gene contains a deletion from 766bp to 6115bp, expression is driven by a sev promoter.

(Fortini et al., 1993)

Allele components

Component

Use(s)

Regulatory region(s)

sev

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Almudi et al., 2009, Purcell and Artavanis-Tsakonas, 1999, Verheyen et al., 1996)

Phenotype Manifest In

cone cell

(Verheyen et al., 1996)

eye

(Almudi et al., 2009, Purcell and Artavanis-Tsakonas, 1999)

ommatidium

(Fortini et al., 1993)

photoreceptor cell R7 | increased number

(Almudi et al., 2009)

photoreceptor neuron

(Verheyen et al., 1996)

Detailed Description

Statement

Reference

Flies carrying N^nucl.sev have a rough eye phenotype and extra R7 photoreceptor cells in the ommatidia.

(Almudi et al., 2009)

Flies expressing N^nucl.sev have a disrupted eye.

(Purcell and Artavanis-Tsakonas, 1999)

Rough eye phenotype.

(Verheyen et al., 1996)

Moderate roughening of the eye surface: many ommatidia display a 'partial lens' morphology.

(Fortini et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

N^nucl.sev has visible phenotype, enhanceable by Rab6^MEF/Rab6[+]

(Purcell and Artavanis-Tsakonas, 1999)

NOT suppressed by

Statement

Reference

N^nucl.sev has visible phenotype, non-suppressible by Socs36E^UASp.cCa/Scer\GAL4^hs.2sev

(Almudi et al., 2009)

Phenotype Manifest In

Enhanced by

Statement

Reference

N^nucl.sev has eye phenotype, enhanceable by Rab6^MEF/Rab6[+]

(Purcell and Artavanis-Tsakonas, 1999)

N^nucl.sev has phenotype, enhanceable by Delta^eA1

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by Delta^eA7

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by Delta^eC5

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by Delta^eCX2

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by Delta^eCY4

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by Delta^eD6

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by Delta^eDL3

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by Delta^eDW2

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by Delta^eE4

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by Delta^eK12

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by Delta^eK1

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by Delta^eM1

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by Delta^eAH5

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by Delta^eO4

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by Egfr^eAO6

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by Egfr^eAW2

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by Egfr^eBP3

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by Egfr^eCH2

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by Egfr^eCP7

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by Egfr^eCS15

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by Egfr^eEM2

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by Egfr^eEP3

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by Egfr^eG1

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by Delta^eAR5

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by Egm¹

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by S^eAL11

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by S^eAS5

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by S^eCJ9

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by S^eDO3

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by S^eE6

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by S^eQ10

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by S^eT6

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by S^eW4

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by Sos^eCN6

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by Delta^eAR6

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by Sos^eCS3

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by Sos^eDN4

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by Sos^eJ2

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by nmo^adk1

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by anon-IX^eA13

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by anon-IX^eJ11

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by anon-VIII^eBB2

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by anon-VIII^eEM1

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by anon-XII^eCP12

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by anon-XII^eCP9

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by Delta^eAT2

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by anon-XII^eCR3

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by anon-XII^eN4

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by anon-XV^3-eAF1

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by anon-XV^4-eCN5

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by anon-XV^eAN4

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by anon-XVI^1-eCN5

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by anon-XVI^sAL4

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by anon-XXIII^eBD1

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by anon-XXIII^eBD4

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by anon-XXIII^eQ7

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by Delta^eAZ5a

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by anon-XXIV^eBG4

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by anon-XXIV^eBU1

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by eH3^eH3

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by eK6^eK6

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by eZ6^eZ6

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by gl^eP2a

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by ifx^eAQ3

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by ifx^eCO3

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by kis^eAL7

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by kis^eCM2

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by Delta^eB3

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by kis^eCV2

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by kis^eDO1

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by kis^eDV6

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by kis^eE4

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by kis^eEA2

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by kis^eG2

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by kis^eJ6

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by kis^eK15

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by kis^eP18

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by lola^eCF3

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by Delta^eBE1

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by lola^eCQ1

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by lola^eDZ6

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by lola^eES2a-spont

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by mam^eC16

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by mam^eF14

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by sca^eCS5

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by Rab6^eAM4

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by Rab6^eAS1

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by Rab6^eER1

(Verheyen et al., 1996)

N^nucl.sev has phenotype, enhanceable by Delta^eBX1

(Verheyen et al., 1996)

Suppressed by

Statement

Reference

N^nucl.sev has phenotype, suppressible by nmo^adk2

(Verheyen et al., 1996)

N^nucl.sev has phenotype, suppressible by anon-XVIII^sCI1

(Verheyen et al., 1996)

N^nucl.sev has phenotype, suppressible by anon-XVIII^sCM4

(Verheyen et al., 1996)

N^nucl.sev has phenotype, suppressible by sAB1^sAB1

(Verheyen et al., 1996)

N^nucl.sev has phenotype, suppressible by sng^sAK12

(Verheyen et al., 1996)

N^nucl.sev has phenotype, suppressible by sng^sDX1

(Verheyen et al., 1996)

N^nucl.sev has phenotype, suppressible by sng^sK1

(Verheyen et al., 1996)

N^nucl.sev has phenotype, suppressible by sng^sU4

(Verheyen et al., 1996)

N^nucl.sev has phenotype, suppressible by stg^sCG4

(Verheyen et al., 1996)

N^nucl.sev has phenotype, suppressible by stg^sM3

(Verheyen et al., 1996)

N^nucl.sev has phenotype, suppressible by Su(H)^sA21

(Verheyen et al., 1996)

N^nucl.sev has phenotype, suppressible by Su(H)^sK2

(Verheyen et al., 1996)

N^nucl.sev has phenotype, suppressible by Su(H)^sO10

(Verheyen et al., 1996)

N^nucl.sev has phenotype, suppressible by Tbp^sBT1

(Verheyen et al., 1996)

N^nucl.sev has phenotype, suppressible by Tbp^sC4

(Verheyen et al., 1996)

N^nucl.sev has phenotype, suppressible by Tbp^sEU4

(Verheyen et al., 1996)

N^nucl.sev has phenotype, suppressible by Tbp^sO12

(Verheyen et al., 1996)

NOT suppressed by

Statement

Reference

N^nucl.sev has photoreceptor cell R7 | increased number phenotype, non-suppressible by Socs36E^UASp.cCa/Scer\GAL4^hs.2sev

(Almudi et al., 2009)

N^nucl.sev has eye phenotype, non-suppressible by Socs36E^UASp.cCa/Scer\GAL4^hs.2sev

(Almudi et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

The rough eye and extra R7 photoreceptor cell phenotypes caused by N^nucl.sev are not suppressed by expression of Socs36E^{Scer\UAS.P\T.cCa} under the control of Scer\GAL4^hs.2sev.

(Almudi et al., 2009)

Second site dominant suppressors reduce the external roughness of the eye, in addition to causing the overall eye shape to become both rounder and larger, and less refractile. Second site dominant enhancers increase the roughness of the eye, eye shape is smaller and flatter and eyes appear more glossy or shiny.

(Verheyen et al., 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

N^nucl.sev

N^nucl

(Purcell and Artavanis-Tsakonas, 1999)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

Open Close