FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\Rab6MEF
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General Information
Symbol
Dmel\Rab6MEF
Species
D. melanogaster
Name
FlyBase ID
FBal0102870
Feature type
allele
Associated gene
Dmel\Rab6
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Purcell and Artavanis-Tsakonas, 1999)
Mutagen
spontaneous
(Purcell and Artavanis-Tsakonas, 1999)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C313T. Amino acid replacement: R62C.

(Purcell and Artavanis-Tsakonas, 1999)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:12,108,616..12,108,616 [-]
Nucleotide change:

C12108616T

Reported nucleotide change:

C313T|FBrf0111465

Amino acid change:

R62C | Rab6-PA; R62C | Rab6-PB

Reported amino acid change:

R62C|FBrf0111465

Comment:

position of mutation based on amino acid coordinate; nucleotide change coordinate given inFBrf0111465 does not agree with amino acid coordinate

(Purcell and Artavanis-Tsakonas, 1999)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes have a wild-type eye.

      (Purcell and Artavanis-Tsakonas, 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Rab6MEF/Rab6[+] is an enhancer of visible phenotype of Nnucl.sev

      (Purcell and Artavanis-Tsakonas, 1999)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Rab6MEF/Rab6[+] is an enhancer of eye phenotype of Nnucl.sev

      (Purcell and Artavanis-Tsakonas, 1999)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Arose in: a w1118 stock. Rab6eER1, Rab6eAM4 and Rab6eAS1 were all induced in the same starting stock, and all have the same lesion (Amino acid replacement: R62C), suggesting that the mutation existed in the genetic background of the starting stock. The Rab6MEF allele, a spontaneous allele from the same starting stock, also contains the same lesion.

      (Purcell and Artavanis-Tsakonas, 1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Rab6MEF
      Name Synonyms
      Secondary FlyBase IDs
        References (1)