FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ana1
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General Information
Symbol
Dmel\ana1
Species
D. melanogaster
Name
FlyBase ID
FBal0030485
Feature type
allele
Associated gene
Dmel\ana
Associated Insertion(s)
P{A92}ana1
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Park et al., 1997, Ebens et al., 1993)
Mutagen
Delta2-3 transposase
(Ebens et al., 1993)
P-element activity
(Park et al., 1997)
Progenitor genotype
Associated Insertion(s)
P{A92}ana1
Cytology
Description

Insertion of a P{lacZ} element.

(Park et al., 1997)
Allele components
Component
Use(s)
Inserted element
P{A92}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous adults have no gross morphological abnormalities. These adults do not live for long after eclosion under crowded conditions in competition with wild-type siblings. Homozygous ana1 larvae show a reduced response to ethyl acetate in an olfactory assay compared to wild-type or ana1; ana+mEa larvae.

      (Park et al., 1997)

      Variable phenotype, ranging from subtle misrouting of fiber tracts to massive disorganization of the adult optic lobes. BrdU experiments reveal that optic lobe neuroblasts enter S phase earlier than in normal development. Early proliferation also occurs in central brain neuroblasts. Neuronal differentiation also occurred early.

      (Ebens et al., 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      ana[+]/ana1 is a suppressor | partially of type I neuroblast | somatic clone | third instar larval stage phenotype of mir-124Δ177.w+

      (Weng and Cohen, 2012)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The mitotic index of type I mir-124Δ177.w+ neuroblast clones is restored to an almost normal value in a ana1/+ background.

      (Weng and Cohen, 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      ana1 is rescued by ana+mEa

      (Ebens et al., 1993)

      ana1 is rescued by ana+t9.3

      (Ebens et al., 1993)
      Comments

      Rescued by P-elements carrying ana genomic and minigene constructs.

      (Ebens et al., 1993)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Precise excisions of the P element resulted in reversion of the phenotype to wild type.

      (Ebens et al., 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ana1
      (Weng and Cohen, 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)