FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mir-124Δ177.w+
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General Information
Symbol
Dmel\mir-124Δ177.w+
Species
D. melanogaster
Name
FlyBase ID
FBal0267900
Feature type
allele
Associated gene
Dmel\mir-124
Associated Insertion(s)
TI{TI}mir-124Δ177.w+
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Chen et al., 2014)
Mutagen
ends-out gene targeting
(Weng and Cohen, 2012)
Progenitor genotype
Associated Insertion(s)
TI{TI}mir-124Δ177.w+
Cytology
Description

304bp of sequence encompassing the mir-124 hairpin has been deleted and replaced by a mini-w reporter which is flanked firstly by a pair of loxP sites and secondly (flanking the loxP sites) by a pair of inverted attP sites.

(Weng and Cohen, 2012)
Allele components
Component
Use(s)
Also carries
attP
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      mir-124Δ177.w+/Df(2L)Exel7069 females show a significant decrease in median lifespan compared to controls.

      (Chen et al., 2014)

      Homozygous type I neuroblast clones (induced the early first instar larvae and analysed in late third instar larvae) show a reduction in the number of postmitotic neurons per clone and have a reduced mitotic index compared to control clones.

      (Weng and Cohen, 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The mitotic index of type I mir-124Δ177.w+ neuroblast clones is restored to an almost normal value in a ana1/+ background.

      The mitotic index of type I mir-124Δ177.w+ neuroblast clones is restored to an almost normal value if the clones are also expressing anaJF02665 under the control of Scer\GAL4elav.PU.

      (Weng and Cohen, 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      mir-124Δ177.w+ is rescued by Scer\GAL4elav.PU/mir-124UAS.DsRed2

      (Weng and Cohen, 2012)
      Comments

      Expression of mir-124Scer\UAS.T:Disc\RFP-DsRed2 under the control of Scer\GAL4elav.PU rescues the proliferation defects seen in mir-124Δ177.w+ type I neuroblast clones.

      (Weng and Cohen, 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      The phiC31\attP sites present in the cassette that replaces the mir-124 hairpin permit subsequent genetic rescue by recombinase-mediated cassette exchange (RMCE).

      (Weng and Cohen, 2012)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      miR-124Δ177,w+
      (Weng and Cohen, 2012)
      mir-124Δ177.w+
      Δ177
      (Weng and Cohen, 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)