FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\emcE12
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General Information
Symbol
Dmel\emcE12
Species
D. melanogaster
Name
FlyBase ID
FBal0031198
Feature type
allele
Associated gene
Dmel\emc
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    amorphic allele - genetic evidence

    (Brown et al., 1995)
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Cell lethal.

        (Brown et al., 1995)

        The posterior scutellar bristle is displaced from its normal position in emcE12/emc11 flies. emcE12/emc11 neurA101 larvae have very low viability.

        (Huang et al., 1995)

        emc11/emcE12 discs show an increased level of sc protein; clusters are similar to wild type though some are slightly enlarged. Strongly labelled nuclei are present scattered over the presumptive notum; they correspond to precursors of ectopic emc bristles.

        (Cubas et al., 1991)

        ac and sc protein patterns are subtly altered in the wing disc. Novel sites of ac and sc expression in the notal region that later coincide with ectopic sensory organs.

        (Skeath and Carroll, 1991)

        emcE12 homozygous clones and emcE12/emc9 heterozygous clones are cell lethal in wing and notum cells. emcE12/emc1 heterozygous clones have an abnormal size, shape and spatial distribution: differentiate extra sensory elements as well as extra veins.

        (Garcia-Alonso and Garcia-Bellido, 1988)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhancer of
        Statement
        Reference

        emcE12 is an enhancer of visible phenotype of Scer\GAL4455.2, l(1)scUAS.cHa

        (Rottgen et al., 1998)
        Phenotype Manifest In
        Enhancer of
        Statement
        Reference

        emcE12 is an enhancer of scutellar bristle phenotype of Scer\GAL4455.2, l(1)scUAS.cHa

        (Rottgen et al., 1998)
        Other
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The addition of ttkrM730/+ or Df(3R)awd-KRB to emcE12/+ animals leads to a weak ectopic wing margin bristle phenotype.

        (Badenhorst et al., 2002)

        Mutation enhances the ectopic scutellar bristle phenotype seen from Scer\GAL4455.2-mediated expression of l(1)scScer\UAS.cHa.

        (Rottgen et al., 1998)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        emcE12
        Name Synonyms
        Secondary FlyBase IDs
          References (9)