FB2026_03 , released September 17, 2026
Allele: Dmel\fafB6
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General Information
Symbol
Dmel\fafB6
Species
D. melanogaster
Name
FlyBase ID
FBal0031242
Feature type
allele
Associated gene
Dmel\faf
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Fischer-Vize et al., 1992)
Mutagen
ethyl methanesulfonate
(Fischer-Vize et al., 1992)
Progenitor genotype
Cytology
Description

Amino acid replacement: W459term.

(Chen and Fischer, 2000)

Nucleotide substitution: G?A.

(Chen and Fischer, 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:31,780,497..31,780,497 [+]
Nucleotide change:

G31780497A

Reported nucleotide change:

G?A

Amino acid change:

W459term | faf-PA; W459term | faf-PC; W459term | faf-PD; W459term | faf-PE; W459term | faf-PG; W459term | faf-PH; W459term | faf-PI

Reported amino acid change:

W459term

Comment:

TGG to TGA

(Chen and Fischer, 2000)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos derived from fafB4/fafB6 females mated to wild-type males show ventralisation of the cuticle, with a herniated head, defective Filzkorper and denticle belts that extend throughout the ventral half of the cuticle.

      Embryos derived from fafB6/Df(3R)faf-BP females mated to wild-type males show early embryonic lethality associated with blastoderm arrest and do not produce cuticle.

      (Stinchfield et al., 2012)

      Eyes roughened due to abnormalities in the hexagonal facet array: but only 1% of facets are affected. Ovaries of homozygous females are normal in appearance but the embryos produced never form syncytial blastoderm and all fail to hatch.

      (Fischer-Vize et al., 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      fafB6
      (Stinchfield et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)