FlyBase Allele Report: Dmel\faf[B4]

General Information

Symbol

Dmel\faf^B4

Species

D. melanogaster

Name

FlyBase ID

FBal0031240

Feature type

allele

Associated gene

Dmel\faf

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Fischer-Vize et al., 1992)

Mutagen

ethyl methanesulfonate

(Fischer-Vize et al., 1992)

Progenitor genotype

Cytology

Description

Amino acid residue F279 is replaced by NPNNLL due to deletion of a TTT codon and insertion of 18bp (AATCCCAACAATCTACTG).

(Chen and Fischer, 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

delins

3R:31,779,955..31,779,957 [+]

Inserted_sequence:

AATCCCAACAATCTACTG

Comment:

Amino acid residue F279 is replaced by NPNNLL due to deletion of a TTT codon and insertion of 18bp (AATCCCAACAATCTACTG).

(Chen and Fischer, 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

partially lethal - majority die (with Df(3R)faf-BP)

(Stinchfield et al., 2012)

partially lethal - majority die (with faf^B5)

(Stinchfield et al., 2012)

visible | recessive

(Fischer-Vize et al., 1992)

Phenotype Manifest In

embryonic/first instar larval cuticle | non-rescuable maternal effect (with faf^B5)

(Stinchfield et al., 2012)

embryonic/first instar larval cuticle | non-rescuable maternal effect (with faf^B6)

(Stinchfield et al., 2012)

embryonic/first instar larval cuticle | non-rescuable maternal effect (with faf^BX3)

(Stinchfield et al., 2012)

embryonic/first instar larval cuticle | non-rescuable maternal effect (with faf^FO8)

(Stinchfield et al., 2012)

embryonic head | non-rescuable maternal effect (with faf^B5)

(Stinchfield et al., 2012)

embryonic head | non-rescuable maternal effect (with faf^B6)

(Stinchfield et al., 2012)

embryonic head | non-rescuable maternal effect (with faf^BX3)

(Stinchfield et al., 2012)

embryonic head | non-rescuable maternal effect (with faf^FO8)

(Stinchfield et al., 2012)

filzkorper | non-rescuable maternal effect (with faf^B5)

(Stinchfield et al., 2012)

filzkorper | non-rescuable maternal effect (with faf^B6)

(Stinchfield et al., 2012)

filzkorper | non-rescuable maternal effect (with faf^BX3)

(Stinchfield et al., 2012)

filzkorper | non-rescuable maternal effect (with faf^FO8)

(Stinchfield et al., 2012)

ventral denticle belt | ectopic | non-rescuable maternal effect (with faf^BX3)

(Stinchfield et al., 2012)

ventral denticle belt | ectopic | non-rescuable maternal effect (with faf^FO8)

(Stinchfield et al., 2012)

Detailed Description

Statement

Reference

Embryos derived from faf^B4/faf^B5 females mated to wild-type males show modest ventralisation of the cuticle, with a herniated head, poorly developed Filzkorper and slightly extended ventral cuticles.

Embryos derived from faf^B4/faf^B6 females mated to wild-type males show ventralisation of the cuticle, with a herniated head, defective Filzkorper and denticle belts that extend throughout the ventral half of the cuticle.

Embryos derived from faf^B4/faf^FO8 females mated to wild-type males show significant ventralisation of the cuticle, with a herniated head, defective Filzkorper, malformed dorsal cuticle and denticle belts that extend well into the dorsal half of the embryo.

Embryos derived from faf^B4/faf^BX3 females mated to wild-type males show significant ventralisation of the cuticle, with a herniated head, defective Filzkorper, malformed dorsal cuticle and extended denticle belts.

(Stinchfield et al., 2012)

Mutation has no effect on rho^hs.sev rough eye phenotype.

(Freeman, 1994)

Eyes roughened due to abnormalities in the hexagonal facet array: but only 1% of facets are affected. Females are fertile.

(Fischer-Vize et al., 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Med⁸, faf[+]/faf^B4 has partially lethal - majority die | dominant | maternal effect phenotype

(Stinchfield et al., 2012)

Phenotype Manifest In

Other

Statement

Reference

Med⁸, faf[+]/faf^B4 has embryonic/first instar larval cuticle | maternal effect phenotype

(Stinchfield et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Embryos derived from Med⁸/+ females mated to males heterozygous for faf^B4 show semi-lethality. The embryos have a ventralised cuticle.

Embryos derived from faf^B4/+ females mated to Med⁸/+ males have a wild-type cuticle.

(Stinchfield et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

faf^B4

(Stinchfield et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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