FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\hopair
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General Information
Symbol
Dmel\hopair
Species
D. melanogaster
Name
aberrant immune response
FlyBase ID
FBal0031501
Feature type
allele
Associated gene
Dmel\hop
Associated Insertion(s)
P{}hopair
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Zinyk et al., 1993)
Mutagen
P-element activity
(Zinyk et al., 1993, Watson et al., 1991)
PM hybrid dysgenesis
(Hanratty and Dearolf, 1993)
Progenitor genotype
Associated Insertion(s)
P{}hopair
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Melanotic phenotype: encapsulation of abnormal cells or tissues by otherwise normal haemocytes.

      (Hanratty and Dearolf, 1993)

      Autoimmune mutation causing polyphasic lethality with melanotic tumour formation (Watson Dev. Genet. 12:173 ). This developmental arrest is slightly suppressed by awdK, in that average lethal phase shifted later.

      (Zinyk et al., 1993)

      Melanotic tumour formation and lethality are due to the same mutation. Mutations exhibit incomplete penetrance and expressivity of the melanotic tumour phenotype. Small and/or abnormally shaped brain. No visible lymph gland defects.

      (Watson et al., 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      hop[+]/hopair is a suppressor of visible phenotype of CycEJP

      (Brumby et al., 2004)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      hop[+]/hopair is a suppressor of eye phenotype of CycEJP

      (Brumby et al., 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      See Watson Dev. Genet. 12:173 .

      (Zinyk et al., 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      hopair
      Name Synonyms
      aberrant immune response
      (Zinyk et al., 1993)
      Secondary FlyBase IDs
        References (5)