FlyBase Allele Report: Dmel\eIF4A[162-3]

General Information

Symbol

Dmel\eIF4A^162-3

Species

D. melanogaster

Name

FlyBase ID

FBal0031633

Feature type

allele

Associated gene

Dmel\eIF4A

Associated Insertion(s)

P{hsneo.ry⁺}eIF4A^162-3

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Dorn et al., 1993)

Progenitor genotype

Associated Insertion(s)

P{hsneo.ry⁺}eIF4A^162-3

Cytology

Description

Insertion of P{hsneo} between coordinates 0 and 1, in the first intron of the eIF-4a transcription unit.

(Dorn et al., 1993)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:5,982,548..5,982,548 [+]

(Galloni and Edgar, 1999, Rottgen et al., 1998, Dorn et al., 1993)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell number | cell autonomous | larval stage | somatic clone

(Galloni and Edgar, 1999)

lethal | recessive

(Dorn et al., 1993)

lethal - all die before end of larval stage | recessive

(Galloni and Edgar, 1999)

some die during larval stage | recessive

(Galloni and Edgar, 1999)

Phenotype Manifest In

wing disc

(Galloni and Edgar, 1999)

Detailed Description

Statement

Reference

Larval growth delayed, in L3. 45% survive until 5 days after hatching. 4% survive until 10 days after hatching. DNA replication continues. Mutant phenotype is cell autonomous. Mutant clones in the wing disc are detectable but never reach twin spot size. Flies which have had clones induced in them do not show a rough eye phenotype.

(Galloni and Edgar, 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

eIF4A^162-3 is an enhancer of visible phenotype of Df(1)N-8/N^55e11

(Rottgen et al., 1998)

Phenotype Manifest In

Enhancer of

Statement

Reference

eIF4A^162-3 is an enhancer of scutum & macrochaeta | ectopic phenotype of Df(1)N-8/N^55e11

(Rottgen et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

Mutation increases the number of ectopic bristles on the notum of N^55e11/Df(1)N-8 transheterozygotes.

(Rottgen et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

eIF4A^k09406

(Rottgen et al., 1998)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Excision of the P-element is accompanied by reversion of the mutant phenotype.

(Galloni and Edgar, 1999)

Dominant enhancer effect on In(1)w^m4h position-effect variegation due to second site enhancer. Wild type revertants can be generated by Δ2-3 P-element excision.

(Dorn et al., 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

Eif4a^162-3

eIF-4a^162-3

eIF-4a¹⁶²

eIF4A^162-3

eif4A¹⁶²

(Galloni and Edgar, 1999)

l(2)162³

l(2L)162

(Rottgen et al., 1998)

l(2L)162/neo

(Dorn et al., 1993)

l(2L)162^neo

(Dorn et al., 1993)

Name Synonyms

Secondary FlyBase IDs

FBal0096980

References (3)

Report Sections

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