FlyBase Allele Report: Dmel\E(bx)[ry122]

General Information

Symbol

Dmel\E(bx)^ry122

Species

D. melanogaster

Name

FlyBase ID

FBal0031830

Feature type

allele

Associated gene

Dmel\E(bx)

Associated Insertion(s)

P{ry11}E(bx)^ry122

Carried in Construct

Also Known As

Nurf301¹

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Berg and Spradling, 1991)

Progenitor genotype

Associated Insertion(s)

P{ry11}E(bx)^ry122

Cytology

Description

The P{ry11} insertion is within the untranslated leader sequence of E(bx).

(Badenhorst et al., 2002)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with Df(3L)ED201)

(Miller et al., 2020)

lethal | germline clone | maternal effect (with Df(3L)3643)

(Badenhorst et al., 2002)

lethal | recessive

(Berg and Spradling, 1991)

Phenotype Manifest In

dendrite

(Parrish et al., 2006)

embryonic/larval hemocyte | increased number

(Ragab, 2006)

melanotic mass (with E(bx)^Nurf301-2)

(Badenhorst et al., 2002)

melanotic mass (with E(bx)^Nurf301-3)

(Badenhorst et al., 2002)

Detailed Description

Statement

Reference

E(bx)^ry122 mutants show class I dendrite branching defects at late larval stages.

(Parrish et al., 2006)

E(bx)^ry122 mutants have a high incidence of melanotic tumours and an increased number of larval hemocytes.

(Ragab, 2006)

The male X chromosome in E(bx)^ry122/Df(3L)3643 mutants is highly aberrant. E(bx)^Nurf301-2/E(bx)^ry122 and E(bx)^ry122/E(bx)^Nurf301-3 mutant larvae exhibit melanotic tumours.

(Badenhorst et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

E(bx)^ry122 has neoplasia phenotype, non-suppressible by Df(2R)ED3921

(Ragab, 2006)

Enhancer of

Statement

Reference

E(bx)^ry122/E(bx)[+] is an enhancer of visible | dominant phenotype of gcm^Pyx

(Popkova et al., 2012)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

E(bx)^ry122 has embryonic/larval hemocyte | increased number phenotype, non-suppressible by Df(2R)ED3921

(Ragab, 2006)

Enhancer of

Statement

Reference

E(bx)^ry122/E(bx)[+] is an enhancer of chaeta | increased number phenotype of gcm^Pyx

(Popkova et al., 2012)

E(bx)^ry122/E(bx)[+] is an enhancer of dorsal appendage | maternal effect phenotype of EcR^{B1-ΔC655.F645A.UAS}, Scer\GAL4^slbo.2.6

(Badenhorst et al., 2005)

E(bx)^ry122 is an enhancer of adult metathoracic segment phenotype of Ubx^6.28/Ubx^bx-34e

(Badenhorst et al., 2002)

E(bx)^ry122 is an enhancer of haltere phenotype of Ubx^6.28/Ubx^bx-34e

(Badenhorst et al., 2002)

E(bx)^ry122 is an enhancer of wing | ectopic phenotype of Ubx^6.28/Ubx^bx-34e

(Badenhorst et al., 2002)

E(bx)^ry122 is an enhancer of adult mesothoracic segment | anterior | ectopic phenotype of Ubx^6.28/Ubx^bx-34e

(Badenhorst et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Df(2R)ED3921 fails to suppress the melanotic tumour and increased larval hemocyte number of E(bx)^ry122 mutants.

(Ragab, 2006)

The frequency of abnormal dorsal appendages in embryos derived from females carrying EcR^{B1-ΔC655.F645A.Scer\UAS} under the control of Scer\GAL4^slbo.2.6 (23%) is increased if the females are also heterozygous for E(bx)^ry122 (84%).

(Badenhorst et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

E(bx)^Nurf301-2

(Badenhorst et al., 2002)

E(bx)^Nurf301-3

(Badenhorst et al., 2002)

E(bx)^Nurf301-4

(Badenhorst et al., 2002)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

10628

P{ry11}E(bx)^ry122, mwh¹ ry⁵⁰⁶ e¹/TM3, ry^RK Sb¹ Ser¹

Notes on Origin

Discoverer

A. Spradling.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

E(bx)^ry122

(Parrish et al., 2006)

Ebx^ry122

(Li et al., 2010)

Nurf301¹

(Badenhorst et al., 2005)

l(3)122¹

(Bloomington Drosophila Stock Center, 2000.1.31)

l(3)ry122¹

nurf301¹

(Ragab, 2006, Badenhorst et al., 2002)

ry122

(Berg and Spradling, 1991)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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