FlyBase Allele Report: Dmel\Tm2[C10]

General Information

Symbol

Dmel\Tm2^C10

Species

D. melanogaster

Name

FlyBase ID

FBal0032024

Feature type

allele

Associated gene

Dmel\Tm2

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

PM hybrid dysgenesis

Nature of the Allele

Allele class

loss of function allele

(Kreuz et al., 1996)

Mutagen

PM hybrid dysgenesis

(Kreuz et al., 1996)

Progenitor genotype

Cytology

Description

Deletion of approximately 3.0kb. The breakpoints are within introns 1 and 4, resulting in the deletion of exons 2, 3 and 4.

(Kreuz et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

flightless | dominant

(Kreuz et al., 1996)

lethal - all die during embryonic stage | recessive

(Kreuz et al., 1996)

some die during embryonic stage | recessive

(Kreuz et al., 1996)

Phenotype Manifest In

indirect flight muscle cell

(Kreuz et al., 1996)

Detailed Description

Statement

Reference

The core of the myofibrillar lattice is well preserved in the indirect flight muscles of heterozygotes, although it is disrupted at the periphery, where the thick and thin filaments detach from the main core. The diameter of each myofibril is reduced to approximately 25 to 27 thick filaments. The core of myofibrils of the indirect flight muscles is reduced to 16 +/- 2.0 thick filaments in Tm2³/Tm2^C10 transheterozygotes.

(Kreuz et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Tm2^C10/Tm2[+] is a suppressor of visible phenotype of wupA^hdp-2

(Naimi et al., 2001)

Phenotype Manifest In

Suppressor of

Statement

Reference

Tm2^C10/Tm2[+] is a suppressor of indirect flight muscle cell phenotype of wupA^hdp-2

(Naimi et al., 2001)

Tm2^C10/Tm2[+] is a suppressor of wing phenotype of wupA^hdp-2

(Naimi et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

The upheld wing phenotype of wupA^hdp-2 flies is partially suppressed by Tm2^C10/+. The IFM hypercontraction phenotype seen in wupA^hdp-2 flies is partially suppressed by Tm2^C10/+.

(Naimi et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Tm2^C10 is rescued by Tm2^+tΔ-2500

(Kreuz et al., 1996)

Comments

The flightless behaviour and recessive lethality caused by Tm2^C10 are completely rescued by Tm2^+tΔ-2500.

(Kreuz et al., 1996)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

C10

(Naimi et al., 2001)

Tm2^C10

Tm2^nc99Eb-C10

l(3)nc99Eb^C10

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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