FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mei-S3328
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General Information
Symbol
Dmel\mei-S3328
Species
D. melanogaster
Name
FlyBase ID
FBal0032121
Feature type
allele
Associated gene
Dmel\mei-S332
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Kerrebrock et al., 1995)
Mutagen
ethyl methanesulfonate
(Kerrebrock et al., 1995, Kerrebrock et al., 1992)
Progenitor genotype
Cytology
Description

Amino acid replacement: V34E. V34 falls within the predicted coiled coil.

(Kerrebrock et al., 1995)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:22,123,098..22,123,098 [+]
Nucleotide change:

T22123098A

Amino acid change:

V34E | mei-S332-PA; V34E | mei-S332-PB

Reported amino acid change:

V34E

Comment:

V34 falls within the predicted coiled coil.

(Kerrebrock et al., 1995)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Hemizygous flies show high frequencies of chromosome loss and mis-segregation in male meiosis II.

      (Tang et al., 1998)

      Levels of nondisjunction are higher in males than females.

      (Kerrebrock et al., 1995)

      Defects in sister chromatid cohesion. 20--30% total non-disjunction: male predominant nondisjunction. Hemizygotes exhibited a small increase in total nondisjunction. High frequency of premature separation of sister chromatids in prophase II. Nondisjunction of chromosomes 2 and 3 in males.

      (Kerrebrock et al., 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The non-disjunction phenotype seen in mei-S3328/+ sperm is partially suppressed by polo1, poloS025604, poloS132408 or Df(3L)rdgC-co2.

      (Clarke et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Complements

      mei-S3326

      (Tang et al., 1998)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Strong mei-S332 allele.

      (Kerrebrock et al., 1992)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      mei-S3328
      (Yan et al., 2010, Clarke et al., 2005)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)