FlyBase Allele Report: Dmel\mys[xR04]

General Information

Symbol

Dmel\mys^xR04

Species

D. melanogaster

Name

FlyBase ID

FBal0032209

Feature type

allele

Associated gene

Dmel\mys

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

antimorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

antimorphic allele - genetic evidence

(Jannuzi et al., 2004, Jannuzi et al., 2002, Zusman et al., 1993, Bunch et al., 1992, Wilcox et al., 1989)

Mutagen

ethyl methanesulfonate

(Jannuzi et al., 2002, Wilcox et al., 1989)

Progenitor genotype

Cytology

Description

Nucleotide substitution: G?A. Mutation at the exon 7 splice acceptor site, resulting in a frameshift after amino acid residue 825.

(Jannuzi et al., 2002)

Indistinguishable from wild type on Southern blot. Immunoblots indicate β_PS protein levels are comparable to wild type (within a factor of two).

(Bunch et al., 1992)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:8,068,869..8,068,869 [+]

Nucleotide change:

G8068869A

Comment:

G to A base change at the splice acceptor. Causes a frameshift after aa residue 825.

(Jannuzi et al., 2002)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with mys^b7)

(Jannuzi et al., 2002)

lethal - all die during embryonic stage

(Bunch et al., 1992)

lethal - all die during embryonic stage | recessive

(Drysdale et al., 1993)

some die during embryonic stage

(Bunch et al., 1992)

some die during embryonic stage | recessive

(Drysdale et al., 1993)

Phenotype Manifest In

embryo | extended germ band stage | germline clone

(Roote and Zusman, 1995)

eye

(Zusman et al., 1993)

stomodeum | germline clone

(Roote and Zusman, 1995)

Detailed Description

Statement

Reference

Hemizygous embryos derived from heterozygous females often have a "tail up" phenotype.

(Jannuzi et al., 2002)

90-100% double heterozygotes with amorphic if mutations die. Double heterozygotes with hypomorphic if mutations show partial genetic interaction. Class II and III if mutations show almost no genetic interaction.

(Bloor and Brown, 1998)

In embryos derived from mutant germline, at the end of germband retraction the anterior ventral cells of the germband move slightly more anteriorly than corresponding tissue in wild type animals. This phenotype is more extreme than for the simple loss of function mys¹¹. The opening of the stomodeum has moved to the anterior tip of the embryo.

(Roote and Zusman, 1995)

Widespread muscle attachment abnormality in embryo, consequently mobility is impaired.

(Drysdale et al., 1993)

mys^xR04/mys⁸ flies die at 25^oC but survive at 18^oC, and have inflated or blistered wings and often show a gap between the pigment cell feet constituting the fenestrated membrane and the layer of pigmented subretinal cells found below the basement membrane.

(Zusman et al., 1993)

Variability of morphological and immunostaining phenotypes. Some embryos that are clearly mys^xR04 based on head phenotypes had β_PS staining at muscle attachment sites.

(Bunch et al., 1992)

Heterozygotes with mys⁸ are lethal.

(Wilcox et al., 1989)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

mys[+]/mys^xR04 is a non-enhancer of visible | dominant phenotype of sog^EP7

(Araujo et al., 2003)

mys[+]/mys^xR04 is a non-enhancer of visible | dominant phenotype of sog^EP11

(Araujo et al., 2003)

NOT Suppressor of

Statement

Reference

mys[+]/mys^xR04 is a non-suppressor of visible | dominant phenotype of sog^EP11

(Araujo et al., 2003)

mys[+]/mys^xR04 is a non-suppressor of visible | dominant phenotype of sog^EP7

(Araujo et al., 2003)

Other

Statement

Reference

if^unspecified, mys^xR04 has lethal | dominant phenotype

(Jannuzi et al., 2002)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

mys[+]/mys^xR04 is a non-enhancer of wing vein phenotype of sog^EP7

(Araujo et al., 2003)

mys[+]/mys^xR04 is a non-enhancer of wing vein phenotype of sog^EP11

(Araujo et al., 2003)

NOT Suppressor of

Statement

Reference

mys[+]/mys^xR04 is a non-suppressor of wing vein phenotype of sog^EP11

(Araujo et al., 2003)

mys[+]/mys^xR04 is a non-suppressor of wing vein phenotype of sog^EP7

(Araujo et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

mys^ts3

(Bunch et al., 1992)

mys^ts2

(Bunch et al., 1992)

Fails to complement

mys^b13

(Jannuzi et al., 2004)

mys^b1

(Jannuzi et al., 2004)

mys^b20

(Jannuzi et al., 2004)

mys^b21

(Jannuzi et al., 2004)

mys^b22

(Jannuzi et al., 2004)

mys^b23

(Jannuzi et al., 2004)

mys^b24

(Jannuzi et al., 2004)

mys^b25

(Jannuzi et al., 2004)

mys^b26

(Jannuzi et al., 2004)

mys^b27

(Jannuzi et al., 2004)

mys^b28

(Jannuzi et al., 2004)

mys^b29

(Jannuzi et al., 2004)

mys^b30

(Jannuzi et al., 2004)

mys^b31

(Jannuzi et al., 2004)

mys^b32

(Jannuzi et al., 2004)

mys^b33

(Jannuzi et al., 2004)

mys^b34

(Jannuzi et al., 2004)

mys^b36

(Jannuzi et al., 2004)

mys^b37

(Jannuzi et al., 2004)

mys^b38

(Jannuzi et al., 2004)

mys^b39

(Jannuzi et al., 2004)

mys^b3

(Jannuzi et al., 2004)

mys^b40

(Jannuzi et al., 2004)

mys^b41

(Jannuzi et al., 2004)

mys^b42

(Jannuzi et al., 2004)

mys^b43

(Jannuzi et al., 2004)

mys^b44

(Jannuzi et al., 2004)

mys^b45

(Jannuzi et al., 2004)

mys^b46

(Jannuzi et al., 2004)

mys^b47

(Jannuzi et al., 2004)

mys^b48

(Jannuzi et al., 2004)

mys^b49

(Jannuzi et al., 2004)

mys^b4

(Jannuzi et al., 2004)

mys^b50

(Jannuzi et al., 2004)

mys^b51

(Jannuzi et al., 2004)

mys^b52

(Jannuzi et al., 2004)

mys^b53

(Jannuzi et al., 2004)

mys^b55

(Jannuzi et al., 2004)

mys^b56

(Jannuzi et al., 2004)

mys^b57

(Jannuzi et al., 2004)

mys^b58

(Jannuzi et al., 2004)

mys^b59

(Jannuzi et al., 2004)

mys^b5

(Jannuzi et al., 2004)

mys^b60

(Jannuzi et al., 2004)

mys^b61

(Jannuzi et al., 2004)

mys^b62

(Jannuzi et al., 2004)

mys^b63

(Jannuzi et al., 2004)

mys^b64

(Jannuzi et al., 2004)

mys^b65

(Jannuzi et al., 2004)

mys^b66

(Jannuzi et al., 2004)

mys^b67

(Jannuzi et al., 2004)

mys^b68

(Jannuzi et al., 2004)

mys^b69

(Jannuzi et al., 2004)

mys^b70

(Jannuzi et al., 2004)

mys^b8

(Jannuzi et al., 2004)

mys^b7

(Jannuzi et al., 2004)

mys^b9

(Jannuzi et al., 2004)

mys^ts1

(Bunch et al., 1992)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

l(1)mys^xR04

(Wilcox et al., 1989)

mys^XR04

(Jannuzi et al., 2004, Jannuzi et al., 2002, Bloor and Brown, 1998, Roote and Zusman, 1995)

mys^xR04

Name Synonyms

Secondary FlyBase IDs

References (9)

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