FlyBase Allele Report: Dmel\Syt1[T7]

General Information

Symbol

Dmel\Syt1^T7

Species

D. melanogaster

Name

FlyBase ID

FBal0032854

Feature type

allele

Associated gene

Dmel\Syt1

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Littleton et al., 1994)

loss of function allele

(Littleton et al., 1993)

Mutagen

ethyl methanesulfonate

(Littleton and Bellen, 1994, Littleton et al., 1994, Littleton et al., 1993)

Progenitor genotype

Cytology

Description

No obvious rearrangement as detected by Southern blot.

(Littleton et al., 1993)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neurophysiology (with Syt1^AD1)

(Poskanzer et al., 2006, Littleton et al., 2001)

abnormal neurophysiology (with Syt1^AD3)

(Poskanzer et al., 2006)

lethal

(Littleton and Bellen, 1994)

lethal | recessive

(Littleton et al., 1993)

lethal - all die during embryonic stage | recessive

(Littleton et al., 1994)

some die during embryonic stage | recessive

(Littleton et al., 1994)

Phenotype Manifest In

synaptic vesicle (with Syt1^AD1)

(Littleton et al., 2001)

Detailed Description

Statement

Reference

Syt1^AD1/Syt1^T7 synapses (which lack the C[[2]]B domain) exhibit decreased evoked neurotransmitter release compared to wild-type controls.

Syt1^AD3/Syt1^T7 synapses have a rate constant that is not statistically different from wild-type controls.

(Poskanzer et al., 2006)

There is a decrease in the overall number of synaptic vesicles at the photoreceptor synapses in syt^AD1/syt^T7 mutants.

(Littleton et al., 2001)

No obvious morphological defects.

(Littleton and Bellen, 1994)

Transheterozygote combinations with other syt alleles are lethal.

(Littleton et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Isolated on basis of failure to complement Df(2L)DTD2. The syt alleles form a series: going from most severe to least severe, syt^N19 = syt^N6 >= syt^T7 = syt^T41 > syt^T77 = syt^66.4 > syt^T11.

(Littleton et al., 1993)

Mutant phenotype cannot be rescued when homozygous but can when in trans to syt^N6 by syt^elav.PD.

(Littleton et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Syt1^T7

(Poskanzer et al., 2006)

syt^T7

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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