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General Information
Symbol
Dmel\vasAS
Species
D. melanogaster
Name
FlyBase ID
FBal0033075
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    point mutation
    Nucleotide change:

    C15073600T

    Reported nucleotide change:

    C?T

    Amino acid change:

    H520Y | vas-PA; H520Y | vas-PB; H520Y | vas-PC

    Reported amino acid change:

    H520Y

    Comment:

    Lasko, 2000.2.7, personal communication

    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Amino acid replacement: H520Y.

    Amino acid replacement: H520Y. Nucleotide substitution is of TAT for CAT, in the 425 amino stretch that is highly similar among DEAD-box proteins.

    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference

    Oocytes from vasAS females shows normal levels of vas protein throughout oogenesis but its posterior localization is greatly reduced.

     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    vasAS does not modify PEV, as assayed using the y PEV reporter line P{SUPor-P}B079.

    Very few nuage clusters and particles remain in homozygous nurse cells. Nuage is completely disrupted in the spermatocytes of mutant males.

    Reduced posterior vas localization in the oocyte.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (2)
    Reported As
    Name Synonyms
    Secondary FlyBase IDs
      References (8)