FB2021_01, released Feb 18, 2021

Allele: Dmel\vasAS

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General Information
Symbol
Dmel\vasAS
Species
D. melanogaster
Name
FlyBase ID
FBal0033075
Feature type
allele
Associated gene
Dmel\vas
Associated Insertion(s)
Carried in Construct
Genomic Maps
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    point mutation
    2L:15,073,600..15,073,600 [+]
    Nucleotide change:

    C15073600T

    Reported nucleotide change:

    C?T

    Amino acid change:

    H520Y | vas-PA; H520Y | vas-PB; H520Y | vas-PC

    Reported amino acid change:

    H520Y

    Comment:

    Lasko, 2000.2.7, personal communication

    (Liang et al., 1994)
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
         
        Progenitor genotype
        Cytology
        Nature of the lesion
        Statement
        Reference

        Amino acid replacement: H520Y.

        (Lasko, 2000.2.1)

        Amino acid replacement: H520Y. Nucleotide substitution is of TAT for CAT, in the 425 amino stretch that is highly similar among DEAD-box proteins.

        (Liang et al., 1994)
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference

        Oocytes from vasAS females shows normal levels of vas protein throughout oogenesis but its posterior localization is greatly reduced.

        (Lasko and Ashburner, 1990)
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        vasAS does not modify PEV, as assayed using the y PEV reporter line P{SUPor-P}B079.

        (Gracheva et al., 2009)

        Very few nuage clusters and particles remain in homozygous nurse cells. Nuage is completely disrupted in the spermatocytes of mutant males.

        (Snee and Macdonald, 2004)

        Reduced posterior vas localization in the oocyte.

        (Lasko and Ashburner, 1990)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Complements

        solounspecified

        (Yan et al., 2010)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        AS
        (Yan et al., 2010)
        vasAS
        (Gracheva et al., 2009, Snee and Macdonald, 2004, Lasko, 2000.2.1)
        Name Synonyms
        Secondary FlyBase IDs
          References (8)