FlyBase Allele Report: Dmel\chic[gdh-5]

General Information

Symbol

Dmel\chic^gdh-5

Species

D. melanogaster

Name

FlyBase ID

FBal0034344

Feature type

allele

Associated gene

Dmel\chic

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

antimorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

antimorphic allele - genetic evidence

(Doberstein et al., 1995)

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | embryonic stage

(Kim et al., 2001)

Phenotype Manifest In

crossvein | ectopic

(Doberstein et al., 1995)

larval intersegmental nerve

(Kim et al., 2001)

Detailed Description

Statement

Reference

Homozygous embryos do not have gaps in the pCC/MP2 pathway.

Mutant embryos show defects in motor axon extension, including the ISNb branch.

(Kim et al., 2001)

24% heterozygotes have ectopic wing crossveins.

(Doberstein et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

chic^gdh-5 has abnormal neuroanatomy | embryonic stage phenotype, enhanceable by Ggal\Cam^{KA.ftz.Tag:MT(Khc)}

(Kim et al., 2001)

Suppressor of

Statement

Reference

chic^gdh-5 is a suppressor of abnormal neuroanatomy | embryonic stage phenotype of Ggal\Cam^{KA.ftz.Tag:MT(Khc)}

(Kim et al., 2001)

Phenotype Manifest In

Enhanced by

Statement

Reference

chic^gdh-5 has larval intersegmental nerve phenotype, enhanceable by Ggal\Cam^{KA.ftz.Tag:MT(Khc)}

(Kim et al., 2001)

Suppressor of

Statement

Reference

chic^gdh-5 is a suppressor of pCC neuron phenotype of Ggal\Cam^{KA.ftz.Tag:MT(Khc)}

(Kim et al., 2001)

chic^gdh-5 is a suppressor of vMP2 neuron phenotype of Ggal\Cam^{KA.ftz.Tag:MT(Khc)}

(Kim et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

The abnormal midline crossing of axons seen in robo¹ heterozygotes is suppressed if the embryos are also heterozygous for chic^gdh-5.

(Kim et al., 2001)

Xenogenetic Interactions

Statement

Reference

Only 17% of hemisegments have gaps in the pCC/MP2 pathway in Khc::Ggal\MLCK^KA.ftz chic^gdh-5 double homozygous embryos.

The frequency of motor neuron axon stalls seen in chic^gdh-5 embryos is increased by Khc::Ggal\MLCK^KA.ftz.

(Kim et al., 2001)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

A competitive inhibitor of wild type prolifin.

(Doberstein et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

chi^gdh-5

chic^gdh-5

chic^gdh5

(Kim et al., 2001)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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