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General Information
Symbol
Dmel\dsh75
Species
D. melanogaster
Name
FlyBase ID
FBal0034439
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
    Nature of the Allele
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    dsh75/+ flies display wild-type hair patterns on the wing, thorax and eyes.

    Homozygous clones in the wing result in ectopic bristles and notched wings.

    Homozygous clones induced during the first larval instar show dramatic phenotypes in the dorsal wing hinge; dorsal hinge structures, with the exception of axillary sclerite 1, are obliterated if they fall within the clone. Homozygous clones in the proximal wing hinge result in duplication of the axillary pouch and the yellow club. The pleural wing process and pleural sclerite can also be missing.

    Embryos deficient for maternal and zygotic dsh show a dorsal-open phenotype.

    Embryos zygotically and maternally mutant for dsh75 show a complete absence of heart precursors. sggM11 dsh75 double mutant embryos have the same phenotype as sggM11 single mutant embryos.

    Homozygous clones in the anterior ventral region of the leg disc produce bifurcated or triplicated legs. Homozygous clones close to the proximal edge of the leg disc can produce a complete secondary leg. Clones located more distally can produce converging pattern triplications. Clones in the posterior compartment induce the formation of extra rows of mutant bristles. Clones in the dorsal third of the leg have no effect on pattern. sggM1-1 dsh75 double mutant clones behave like sggM1-1 single mutant clones.

    Embryos exhibit a lawn of denticle belts.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    NOT Enhanced by
    Statement
    Reference

    dsh75 has phenotype, non-enhanceable by nkddsRNA.cRa

    dsh75 has phenotype, non-enhanceable by Apc2ΔS

    NOT suppressed by
    Statement
    Reference

    dsh75 has phenotype, non-suppressible by nkddsRNA.cRa

    dsh75 has phenotype, non-suppressible by Apc2ΔS

    Other
    Statement
    Reference
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    Double-heterozygous flies of the genotype dsh[75]/+ together with either kmr1/+ or kmr2/+ display misoriented hair patterns on the wing, thorax and eyes, while single heterozygotes exhibit phenotypes similar to wild-type controls.

    Injection of nkddsRNA.cRa dsRNA has no effect on the dsh75 phenotype.

    The dsh75 mutant phenotype (embryos both maternally and zygotically homozygous for dsh75) is not affected if the embryos are also maternally and zygotically homozygous for Apc2ΔS.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (1)
    Notes on Origin
    Discoverer
    Comments
    Comments

    Used in mosaic analysis in the wing to examine the effect of inability to respond to wg signal.

    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (1)
    Reported As
    Symbol Synonym
    Name Synonyms
    Secondary FlyBase IDs
      References (17)