FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Cyp303a1AS96
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General Information
Symbol
Dmel\Cyp303a1AS96
Species
D. melanogaster
Name
FlyBase ID
FBal0034989
Feature type
allele
Associated gene
Dmel\Cyp303a1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Ashburner et al., 1999.10.12, Roote, 1995.5.4)
Progenitor genotype
Cytology
Description

Amino acid replacement: P28L.

(Wu et al., 2019)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:16,294,433..16,294,433 [+]
Nucleotide change:

C16294433T

Amino acid change:

P28L | Cyp303a1-PA; P28L | Cyp303a1-PB

Reported amino acid change:

P28L

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

(Wu et al., 2019)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Cyp303a1AS96 homozygotes exhibit developmental arrest occurring in the late embryonic stages (st16-17) with an abnormal dorsal vessel (Fasciclin III staining) and lethality (majority die) shortly before dorsal closure completion when compared to controls.

      (Wu et al., 2019)

      Mutant adults exhibit behavioural defects: they have difficulty in walking, are unable to fly, have held-up wings, and are uncoordinated. Cyp303a1AS96/Df(2L)r10 mutant animals have abnormal electrophysiological responses from mechanosensory bristles. Mutants exhibit a dramatic loss in mechanoreceptor potential (MRP). Transepithelial potential (TEP) is also severely reduced, even after voltage clamping of the bristle organ.

      (Willingham and Keil, 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      S. Roth.

      (Roote, 1995.5.4)
      Comments
      Comments

      Phenotypic data included in FBrf0051973.

      (Roote, 1995.5.4)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Cyp303a1<up>< AS96 ></up>
      (Wu et al., 2019)
      Cyp303a1AS96
      l(2)35FbAS96
      (Willingham and Keil, 2004)
      nompH35Fb-AS96
      (Willingham and Keil, 2004)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)