FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\blow1
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General Information
Symbol
Dmel\blow1
Species
D. melanogaster
Name
FlyBase ID
FBal0035059
Feature type
allele
Associated gene
Dmel\blow
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Doberstein et al., 1997)
Mutagen
ethyl methanesulfonate
(Roote, 1995.9.26, Heitzler et al., 1993)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      blow1/blow2 transheterozygote embryos display defects in the migration and morphology of visceral longitudinal muscle founder cells as well as the muscle fusion.

      (Rudolf et al., 2014)

      DA1 muscles contain one or two nuclei in homozygous stage 15 embryos.

      The number of pre-fusion complexes (electron-dense vesicles paired on either side of the fusing plasma membranes) in the myoblasts of late stage 12/early stage 13 mutant embryos is not significantly different from that seen in wild-type embryos.

      (Estrada et al., 2007)

      blow1 mutant myoblasts show enlarged foci, as well as increased numbers of actin foci. Enlarged foci are seen in these mutants from the earliest stages of fusion and foci persist after fusion would be complete in wild-type.

      (Richardson et al., 2007)

      Myoblasts fail during fusion to form myotubes.

      (Doberstein, 1996.1.23)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      blow1 is rescued by Scer\GAL4twi.PG/blowUAS.cJa

      (Jin et al., 2011)

      blow1 is rescued by blowUAS.cJa/Scer\GAL4sns.PK

      (Jin et al., 2011)

      blow1 is rescued by blowtub.PJ

      (Jin et al., 2011)
      Not rescued by

      blow1 is not rescued by blowUAS.cJa/Scer\GAL4kirre-rP298-G4

      (Jin et al., 2011)

      blow1 is not rescued by Scer\GAL4twi.PG/blowΔC173.UAS

      (Jin et al., 2011)

      blow1 is not rescued by blowY378F.tub

      (Jin et al., 2011)
      Comments

      Expressing blowScer\UAS.cJa under the control of Scer\GAL4kirre-rP298 fails to rescue the myoblast fusion defects in blow1.

      Expressing blowScer\UAS.cJa under the control of Scer\GAL4twi.PG or Scer\GAL4sns.PK rescues the myoblast fusion defects in blow1.

      blowtub.PJ rescues the myoblast fusion defects in blow1 mutant embryos.

      blowY378F.tub fails to rescue the myoblast fusion defects in blow1 mutant embryos.

      Expression of blowΔC173.Scer\UAS under the control of Scer\GAL4twi.PG fails to rescue the myoblast fusion defects in blow1 embryos.

      (Jin et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      References (12)