FlyBase Allele Report: Dmel\nonA[9e2-10]

General Information

Symbol

Dmel\nonA^9e2-10

Species

D. melanogaster

Name

FlyBase ID

FBal0035299

Feature type

allele

Associated gene

Dmel\nonA

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

X ray

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Stanewsky et al., 1993)

Mutagen

X ray

(Stanewsky et al., 1993)

Progenitor genotype

Caused by aberration

T(1;4)9e2-10

Cytology

Description

Deletion of 3kb spanning some of the 5' flanking sequence and up to the first intron.

(Stanewsky et al., 1993)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior

(Stanewsky et al., 1993)

abnormal visual behavior

(Stanewsky et al., 1993)

Phenotype Manifest In

Detailed Description

Statement

Reference

The ERG of T(1;4)9e2-10/Y flies carrying P{Dvir\Gpi1^+t12.5} is normal.

(Campesan et al., 2001)

Semi-lethal. Males are pupal lethal with a few adult escapers that are unable to fly and are slow moving. Half of the male flies have slightly raised and extended wings, the others are wild type and capable of robust bouts of courtship song despite their weak locomotor behaviour. The song is polycyclic and construct P{235R11} can rescue the mutant courtship song. Homozygotes lack the light-on and light-off transient spikes, construct P{235R11} can rescue the mutant phenotype. Walking optomotor performance for either direction of pattern movement displays large deficits, complete rescue is possible with the P{2-STOP} construct.

(Stanewsky et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

nonA^9e2-10 has abnormal optomotor response phenotype, suppressible by Dvir\nonA^Δ113

(Campesan et al., 2001)

nonA^9e2-10 has abnormal optomotor response phenotype, suppressible by Dvir\nonA^Δ168-8

(Campesan et al., 2001)

nonA^9e2-10 has abnormal optomotor response phenotype, suppressible by Dvir\nonA^Δ67-4

(Campesan et al., 2001)

nonA^9e2-10 has abnormal optomotor response phenotype, suppressible by Dvir\nonA^+t12.5

(Campesan et al., 2001)

Other

Statement

Reference

Dvir\nonA^Δ113, nonA^9e2-10 has abnormal song phenotype

(Campesan et al., 2001)

Dvir\nonA^Δ168-8, nonA^9e2-10 has abnormal song phenotype

(Campesan et al., 2001)

Dvir\nonA^Δ67-4, nonA^9e2-10 has abnormal song phenotype

(Campesan et al., 2001)

Dvir\nonA^+t12.5, nonA^9e2-10 has abnormal song phenotype

(Campesan et al., 2001)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The song characteristics of D.melanogaster nonA^9e2-10/Y males carrying Dvir\nonA^+t12.5 (or Dvir\nonA^Δ113, Dvir\nonA^Δ67-4 or Dvir\nonA^Δ168-8) show D.virilis-like features while maintaining indicators of "normal" D.melanogaster song output such as the subtle change in PF (intrapulse frequency) during a song burst. The flies also appear to have a D.virilis-like shorter IPI (interpulse interval), even though the other characteristics of the song pulses that have been measured should, indirectly, lead to a longer IPI, suggesting that Dvir\nonA^+t12.5 is playing an active role in reducing IPIs.

(Campesan et al., 2001)

Complementation and Rescue Data

Rescued by

nonA^9e2-10 is rescued by nonA^+t11

(Campesan et al., 2001)

nonA^9e2-10 is rescued by nonA^+t11

(Sandrelli et al., 2001)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

T(1;4)9e2-10 has an associated allele l(1)14Ca^9e2-10 whose phenotype has been rescued by a series of constructs.

(Stanewsky et al., 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

nonA^9e2-10

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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