FlyBase Allele Report: Dmel\slp2[Δ34B]

General Information

Symbol

Dmel\slp2^Δ34B

Species

D. melanogaster

Name

FlyBase ID

FBal0035636

Feature type

allele

Associated gene

Dmel\slp2

Associated Insertion(s)

Carried in Construct

Also Known As

slp^Δ34, slp^Δ34B

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Cadigan et al., 1994, Grossniklaus et al., 1992)

Mutagen

Delta2-3 transposase

(Cadigan et al., 1994, Cadigan et al., 1994, Grossniklaus et al., 1992)

Progenitor genotype

Caused by aberration

Df(2L)slp-Δ34B

Cytology

Description

Deletion of sequences between the insertion point of P{lArB}slp1^A509 to within slp2 completely removing P{lArB}A208.1M2 insertion.

(Grossniklaus et al., 1992)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage

(Grossniklaus et al., 1992)

some die during embryonic stage

(Grossniklaus et al., 1992)

Phenotype Manifest In

abdominal segment 1

(Cadigan et al., 1994)

abdominal segment 2

(Cadigan et al., 1994)

abdominal segment 3

(Cadigan et al., 1994)

abdominal segment 4

(Cadigan et al., 1994)

cuticle

(Cadigan et al., 1994, Grossniklaus et al., 1992)

ventral denticle belt

(Grossniklaus et al., 1992)

Detailed Description

Statement

Reference

Fusion of abdominal segments A1 and A2, and A3 and A4. Naked cuticle found in the posterior part of each segment is either missing or replaced by denticles.

(Cadigan et al., 1994)

Strong slp2 phenotype.

(Grossniklaus et al., 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT suppressed by

Statement

Reference

slp1^Δ34B, slp2^Δ34B has embryonic/larval dorsal vessel & embryonic myoblast phenotype, non-suppressible by Scer\GAL4^twi.PG/wg^UAS.cAa

(Lee and Frasch, 2000)

slp1^Δ34B, slp2^Δ34B has embryonic/larval somatic muscle & embryonic myoblast | dorsal phenotype, non-suppressible by Scer\GAL4^twi.PG/wg^UAS.cAa

(Lee and Frasch, 2000)

Other

Statement

Reference

slp1^Δ34B, slp2^Δ34B has embryonic/larval dorsal vessel & embryonic myoblast phenotype

(Lee and Frasch, 2000)

slp1^Δ34B, slp2^Δ34B has embryonic/larval somatic muscle & embryonic myoblast | dorsal phenotype

(Lee and Frasch, 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Df(2L)slp-Δ34B embryos (which are mutant for both slp1 and slp2) lack eve-expressing heart or muscle precursors.

(Lee and Frasch, 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Induced on: CyO-208.

(Cadigan et al., 1994, Cadigan et al., 1994, Grossniklaus et al., 1992)

Comments

Phenotypic analysis of different slp1 and slp2 alleles establishes an allelic series: slp1¹ < slp1^Δ41E < slp1^A509 < slp1³ < slp1^Δ46G < slp2^Δ66C < slp1^Δ34B = slp2^Δ34B.

(Grossniklaus et al., 1992)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

slp2^Δ34B

slp^Δ34

(Lee and Frasch, 2000, Crozatier et al., 1996, Goriely et al., 1996)

slp^Δ34B

(Piepenburg et al., 2000, Harbecke and Lengyel, 1995)

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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