FlyBase Allele Report: Dmel\Su(H)[IB115]

General Information

Symbol

Dmel\Su(H)^IB115

Species

D. melanogaster

Name

FlyBase ID

FBal0039061

Feature type

allele

Associated gene

Dmel\Su(H)

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Gho et al., 1996, Couso et al., 1995, Schweisguth et al., 1994, Schweisguth and Posakony, 1992)

loss of function allele

(Matsuno et al., 1997)

Mutagen

ethyl methanesulfonate

(Ashburner et al., 1999.10.12, Furukawa et al., 1992)

Progenitor genotype

Cytology

Description

Nonsense mutation in codon 138.

(Schweisguth et al., 1994)

Amino acid replacement: K94term.

(Furukawa et al., 1992)

Nucleotide substitution: A1226T.

(Furukawa et al., 1992)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:15,041,122..15,041,122 [+]

Nucleotide change:

A15041122T

Amino acid change:

K138term | Su(H)-PA; K138term | Su(H)-PC

(Furukawa et al., 1992)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Schimke immuno-osseous dysplasia

modeled by Marcal1^UAS.cBa

(Morimoto et al., 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal memory | adult stage | dominant

(Song et al., 2009)

lethal

(Schweisguth et al., 1994)

lethal - all die before end of pupal stage | recessive

(Song et al., 2009, Schweisguth and Posakony, 1992)

some die during pupal stage | recessive

(Song et al., 2009, Schweisguth and Posakony, 1992)

Phenotype Manifest In

embryonic/larval lymph gland (with Su(H)¹)

(Tokusumi et al., 2010)

embryonic/larval plasmatocyte (with Su(H)¹)

(Tokusumi et al., 2010)

eye-antennal disc

(Schweisguth and Posakony, 1992)

sensory mother cell

(Schweisguth and Posakony, 1992)

wing disc

(Schweisguth and Posakony, 1992)

Detailed Description

Statement

Reference

The number of corpora cardiaca cells is normal in mutant embryos.

(Park et al., 2011)

Su(H)¹/Su(H)^IB115 mutant tissues exhibit a loss of ptc-positive prohemocytes and the overproduction of differentiated plasmatocytes. By contrast, an increase is not observed in the crystal cell population in Su(H)¹/Su(H)^IB115 mutant lymph glands.

(Tokusumi et al., 2010)

Homozygotes are lethal during pupal development.

Heterozygous flies carrying out 10 training sessions to test memory of odours display a lower 24 hour memory in spaced training (rest periods between tasks) compared to control flies.

(Song et al., 2009)

No effect on the faf eye phenotype.

(Huang and Fischer-Vize, 1996)

Su(H)⁸/Su(H)^IB115 wings are reduced to stumps.

(Couso et al., 1995)

Lethality during the first day of pupal development. Supernumerary cells stained in mutant imaginal discs have adopted a sensory organ precursor (SOP) fate instead of the epidermal fate they would normally express. The excess SOPs arise from the proneural clusters of potential precursor cels that appear in the imaginal discs during the development of wild type bristles. The wing pouch region of the wing imaginal disc and the retinal field of the eye-antennal imaginal disc are dramatically reduced. Identical phenotype is seen when transheterozygous with Df(2L)TE35BC-24, Su(H)¹, Su(H)² or Su(H)⁸.

(Schweisguth and Posakony, 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Su(H)[+]/Su(H)^IB115 is an enhancer of visible | dominant phenotype of N^Mcd5

(Ramain et al., 2001)

Su(H)[+]/Su(H)^IB115 is an enhancer of visible | dominant phenotype of N^Mcd1

(Ramain et al., 2001)

Suppressor of

Statement

Reference

Su(H)^IB115 is a suppressor of visible phenotype of N^act.sev

(Matsuno et al., 1997)

Other

Statement

Reference

N^Mcd5, Su(H)^IB115 has visible | somatic clone phenotype

(Ramain et al., 2001)

Phenotype Manifest In

Enhancer of

Statement

Reference

Su(H)[+]/Su(H)^IB115 is an enhancer of adult thorax & microchaeta phenotype of N^Mcd5

(Ramain et al., 2001)

Su(H)[+]/Su(H)^IB115 is an enhancer of adult thorax & microchaeta phenotype of N^Mcd1

(Ramain et al., 2001)

Suppressor of

Statement

Reference

Su(H)^IB115 is a suppressor of photoreceptor cell R3 phenotype of N^act.sev

(Matsuno et al., 1997)

Su(H)^IB115 is a suppressor of photoreceptor cell R4 phenotype of N^act.sev

(Matsuno et al., 1997)

Su(H)^IB115 is a suppressor of photoreceptor cell R7 phenotype of N^act.sev

(Matsuno et al., 1997)

Su(H)^IB115 is a suppressor of phenotype of H¹

(Furukawa et al., 1992)

Other

Statement

Reference

N^Mcd5, Su(H)^IB115 has microchaeta | somatic clone phenotype

(Ramain et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

Su(H)^IB115 dominantly enhances the loss of microchaetae seen in N^Mcd1, N^Mcd5 or N^Mcd8 heterozygotes, reducing the number of microchaetae per heminotum to 64.00 +/- 1.84, 69.92 +/- 1.86 or 79.67 +/- 1.40 respectively.

(Ramain et al., 2001)

Mutation has no detectable effect on the rough eye phenotypes of N^ANK.sev.

(Matsuno et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Su(H)^IB115 is rescued by Su(H)^+t6.0

(Schweisguth et al., 1994)

Su(H)^IB115 is rescued by Su(H)^F

(Schweisguth et al., 1994)

Comments

Neurogenic and lethal phenotype can be fully rescued by Su(H)^+t6.0.

(Schweisguth et al., 1994)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

26661

Su(H)^IB115 fzy¹ cn¹ bw¹ speck¹/CyO

Notes on Origin

Discoverer

Comments

Has no effect the phenotype of N^l1N-ts1/N^fa-g62.

(Fortini and Artavanis-Tsakonas, 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Su(H)^IB115

(Gagliani et al., 2022, Park et al., 2011, Tokusumi et al., 2010, Song et al., 2009)

Name Synonyms

Secondary FlyBase IDs

FBal0034029

References (17)

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