FlyBase Allele Report: Dmel\ash1[29]

General Information

Symbol

Dmel\ash1²⁹

Species

D. melanogaster

Name

FlyBase ID

FBal0039149

Feature type

allele

Associated gene

Dmel\ash1

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

gamma ray

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Tripoulas et al., 1996, LaJeunesse and Shearn, 1995)

Mutagen

gamma ray

(Tripoulas et al., 1996, LaJeunesse and Shearn, 1995, Tripoulas et al., 1994)

Progenitor genotype

Caused by aberration

In(3L)ash1²⁹

Cytology

Description

Inversion that causes the replacement of the carboxyl terminal 350 amino acids (out of a total of 2144 amino acids) with a novel sequence of 21 amino acids.

(LaJeunesse and Shearn, 1996)

Inversion breakpoint within ash1 at nucleotide 6453. Nucleotide sequence beyond the breakpoint is rdgC 5' untranslated region sequence.

(Tripoulas et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Tripoulas et al., 1994)

lethal - all die before end of prepupal stage | recessive

(Tripoulas et al., 1996)

some die during prepupal stage | recessive

(Tripoulas et al., 1996)

Phenotype Manifest In

Detailed Description

Statement

Reference

Phenotypically like ash1²⁸.

(LaJeunesse and Shearn, 1996)

Double heterozygotes with Ubx^abx-1, trx^el2 or brm² exhibit transformation of third leg to second leg identity and haltere to wing transformation.

(Tripoulas et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

ash1²⁹ is a non-suppressor of wing phenotype of Scer\GAL4^OK386, nej^UAS.cMa

(Bantignies et al., 2000)

Other

Statement

Reference

E(z)¹, ash1²⁹ has metathoracic leg phenotype

(LaJeunesse and Shearn, 1996)

E(z)¹, ash1²⁹ has prothoracic leg phenotype

(LaJeunesse and Shearn, 1996)

E(z)⁵, ash1²⁹ has metathoracic leg phenotype

(LaJeunesse and Shearn, 1996)

E(z)⁵, ash1²⁹ has prothoracic leg phenotype

(LaJeunesse and Shearn, 1996)

Df(3L)lxd6, ash1²⁹ has metathoracic leg phenotype

(LaJeunesse and Shearn, 1996)

Df(3L)lxd6, ash1²⁹ has prothoracic leg phenotype

(LaJeunesse and Shearn, 1996)

Additional Comments

Genetic Interactions

Statement

Reference

Double heterozygotes of E(z)⁵, E(z)¹ or Df(3L)lxd6 with ash1²⁹ result in transformations of the third leg to the second leg and first leg to second leg. This phenotype is that expected from partial loss of function of Scr and Ubx.

(LaJeunesse and Shearn, 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Range of lethality for transheterozygotes extends from the third larval instar for the most severe alleles to the pharate adult stage for the least severe alleles.

(Tripoulas et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ash1²⁹

γj9

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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