FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\bs14
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General Information
Symbol
Dmel\bs14
Species
D. melanogaster
Name
FlyBase ID
FBal0039185
Feature type
allele
Associated gene
Dmel\bs
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Fristrom et al., 1994)
Mutagen
ethyl methanesulfonate
(Fristrom et al., 1994)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q102term.

(Montagne et al., 1996)

Mutation lies before the MADS domain.

(Montagne et al., 1996)

Nucleotide substitution: C?T.

(Montagne et al., 1996)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:24,344,393..24,344,393 [+]
Nucleotide change:

C24344393T

Reported nucleotide change:

C?T

Amino acid change:

Q102term | bs-PA; Q102term | bs-PB; Q102term | bs-PC

Reported amino acid change:

Q102term

(Montagne et al., 1996)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygotes have ectopic vein tissue in the wing.

      (Egoz-Matia et al., 2011)

      bs14 homozygous clones in the dorsal air sac primordium grow normally and populate the tip of the air sac primordium to the same degree as wild-type clones

      (Cabernard and Affolter, 2005)

      bs14 embryos show defects in the tracheal system at stage 16, having truncated terminal branches (about 95% penetrance).

      (Han et al., 2004)

      In homozygotes, lethality acts at the 2nd or 3rd larval instar. Mutants show a tracheal phenotype similar to that of bs03267. When heterozygous with wild type, a few additional veins develop.

      (Montagne et al., 1996)

      Mosaic analysis shows that the effect of bs14 is autonomous with respect to the effects on cell size: cells are considerably smaller. However dorsal veins overlying ventral clones are widened and blisters extend beyond clone borders.

      (Fristrom et al., 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      bs14 has visible | dominant phenotype, enhanceable by tx33-2/tx[+]

      (Egoz-Matia et al., 2011)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      bs14 has wing vein | ectopic phenotype, enhanceable by tx33-2/tx[+]

      (Egoz-Matia et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The extra wing vein phenotype of bs14/+ flies is more pronounced if they are also carrying tx33-2/+.

      (Egoz-Matia et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Chromosome carrying bs14 is larval lethal but the basis for the lethality is not clear, though it does map within Df(2R)Px2. Alleles fall into a series in ascending order of severity: bsA48 < bs11 < bs12 < bs13 < bs14 < Df(2R)bs-F31.

      (Fristrom et al., 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      bs14
      (Nachman et al., 2015, Egoz-Matia et al., 2011, Cabernard and Affolter, 2005)
      l(2)F70
      Name Synonyms
      Secondary FlyBase IDs
        References (7)